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Home > Research and Activities > Laboratory of Stem Cell Regulation

Laboratory of Stem Cell Regulation

1. Members

Project leader Kenji Kawabata
Researchers Tomoko Yamaguchi
Postdoctoral associates Yasuhiro Kokubu
Technical assistants Misae Nishijima, Yayoi Kusunoki, Mary Sheryl M. Saldon
Secretary Mika Minamitani

2. Background and Objectives

Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells show the characteristics of self-renewal and pluripotency. In our Lab, functional cells, such as hematopoietic cells, immune cells, hepatic cells, and renal cells, are efficiently differentiated from the stem cells. Our objectives are to establish the novel system of drug screening by using the differentiated cells.

3. Overview of our research

Stem cells, such as embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, show the characteristics of self-renewal and pluripotency. They are expected to apply for the regenerative medicine and the drug development. To do this, stem cells could be efficiently differentiated into functional cells. In our laboratory, functional cells, such as hematopoietic cells, immune cells, and vascular endothelial cells, are efficiently differentiated from stem cells. Our objectives are to use these differentiated cells for the development of novel systems of drug safety test, drug screening systems, and in vitro disease models.

Drug allergy is an important side effect in developing new medicines. Mast cells play a critical role in the allergy responses. However, mast cells are difficult to collect from the body, because they reside in the peripheral tissues but not in the circulation. So, we derive mast cell-like cells from human iPS cells and apply them for development of a novel system of drug allergy test.

The blood brain barrier (BBB) is a bottleneck in development of the central nervous system drugs. BBB is formed by brain vascular endothelial cells and excludes drugs from the brain. In vitro BBB model can help us for the evaluation of drug disposition in the brain. Our interest is that brain vascular endothelial cells are differentiated from iPS cells to construct the in vitro BBB model. Using this model, safety and availability of the central nervous system drugs will be monitored to accelerate drug development.

Laboratory of Stem Cell Regulation

E-mail kawabata*nibiohn.go.jp (replace * by @)

Research and Activities

  • List

    NIBIO

    Coordination Office of Research Ethics
    Department of Research and Development
    Center for Rare Disease Research
    Reverse Translational Research Project
    Platform of Therapeutics for Rare Disease
    Laboratory of Rare Disease Information and Resource Library
    Laboratory of Animal Models for Human Diseases
    Center for Vaccine and Adjuvant Research
    Laboratory of Vaccine Materials
    Laboratory of Regulation of intractable Infectious Diseases
    Laboratory of Immunobiologics Evaluation
    Laboratory of Cell Vaccine
    Laboratory of Mockup Vaccine
    Center for Drug Design Research
    Laboratory of Proteomics for Drug Discovery
    Laboratory of Biopharmaceutical Research
    Laboratory of Antibody Design
    Laboratory of XNA Screening and Design
    Laboratory of Medicinal Plant Screening
    Laboratory of Pharmacokinetic Optimization
    Laboratory of Cell Network Regulation
    Laboratory of Bioimaging and Drug Discovery
    Laboratory of Advanced Biopharmaceuticals
    Laboratory of Clinical and Analytical Chemistry
    Artificial Intelligence Center for Health and Biomedical Research
    Laboratory of Bioinformatics
    Laboratory of In silico design
    AI nutrition project
    Laboratory of Toxicogenomics Informatics
    Laboratory of Proteome Research
    Laboratory of Stem Cell Regulation
    Laboratory of Hepatocyte Regulation
    Laboratory of Cell Cultures
    Section of Laboratory Equipment
    Section of Laboratory Animals
    Research Center for Medicinal Plant Resources
    Tsukuba Primate Research Center
    Laboratory of Infectious Diseases and Immunity
    Laboratory of Nuclear Transport Dynamics
    Laboratory of Gut Environmental System
    KAGAMI Project
    Laboratory of Immunosenescence

    NIHN

    Department of Nutritional Epidemiology and Shokuiku
    Section of the National Health and Nutrition Survey
    Section of Shokuiku
    Section of Dietary Guidelines
    Department of Physical Activity Research
    Section of Behavioral Physiology
    Section of Exercise Guideline
    Section of Healthy Longevity Researches
    Department of Clinical Nutrition
    Section of Nutritional Therapy
    Department of Nutrition and Metabolism
    Section of Chrononutrition
    Section of Energy Metabolism
    Department of Food Function and Labeling
    Section of Food Component Analysis
    Section of Food Safety and Function
    Section of Information Network of Health Food
    International Center for Nutrition and Information
    Section of International Nutrition Strategy
    Section of Population Health Metrics
    Section of Global Disaster Nutrition
    AI Nutrition Research team
    Section of Research Collaboration and Partnership

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