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Home > Research and Activities > Laboratory of Cell Cultures (JCRB Cell Bank)

Laboratory of Cell Cultures (JCRB Cell Bank)

1. Key members

Project Leader Arihiro Kohara
Postdoctoral associates Fumio Kasai, Ryuji Tazawa
Technical assistant Setsuko Shioda, Azusa Ohtani, Midori Ozawa, Noriko Hirayama, Eiko Kawaguchi, Naomi Hara, Masashi Iemura, Hiromi Ikeda, Kohei Kawakami, Akemi Arakawa, Junko Sakai, Yumiko Yamada, Kikuko Ietsuka, Tomoko Tano, Sayaka Miyata, Aya Ohnishi, Nozomi Sugihara
Collaborating Researcher Touho Yoshida, Motonobu Satoh, Takuo Kosaka

2. Background and objectives

The JCRB Cell Bank was originally established in National Institute of Health, Tokyo in 1984. In 2005, the Cell Bank has relocated to the NIBIO, Osaka. The cultured cells represent an in vitro model for numerous studies in medical science and pharmaceutical research. In particular, human-derived cultured cells are indispensable for these studies. As the JCRB cell bank, we are collecting human culture cells derived from various disease patients, and human stem cells including induced pluripotent stem (iPS) cells and adult mesenchymal stem cells. The cells are checked by several strict tests, and then the qualified cells are provided to researchers. Further, we are developing the qualification method, functional evaluation method, and also culture method for human cells in order to support fundamental research on medical or pharmaceutical sciences.

3. Overview of our research

I. JCRB Cell Bank: From the collection to distribution of cells and information

We are collecting human culture cells derived from various disease patients, and human stem cells including induced pluripotent stem (iPS) cells and adult mesenchymal stem cells. The cells are qualified by testing for microbial contamination, virus contamination, and cross culture contamination, and also confirming their karyotype and cell characteristics. And then the qualified cells are provided to researchers. The information of these cells is available at our website, http://cellbank.nibiohn.go.jp/english/

From the collection to distribution of cells

II. Development of quality control procedures and characterization methods for cultured cells

In the cell culture area, mycoplasma contamination, virus contamination and cross contamination with other cell lines are serious problems to be sorted out. We are developing the procedures for testing for microbial contamination, virus contamination, and cross culture contamination. We are also developing characterization methods for culture cell lines. In particular performs a detailed analysis of the genome as a representative of the chromosome analysis of cell lines, it has put a force on the acquisition of the cell information.

Quality control of cells Chromosome analysis in human cell lines

III.Development of new cell lines for drug discovery

Cell lines have been developed as a tool that cannot be essential in drug discovery research. However, the recent genetic modification techniques, improvement of additional tools have been developed. In particular, we are promoting the development of cell lines useful in drug discovery, such as immortalized cells and luciferase expressing cells.

Bio-imaging of luciferase-expressing cells were transplanted into mice

Laboratory of Cell Cultures (JCRB Cell Bank)

Website https://cellbank.nibiohn.go.jp/english/
E-mail jcrb-cell*nibiohn.go.jp (replace * by @)

Research and Activities

  • List

    NIBIO

    Coordination Office of Research Ethics
    Department of Research and Development
    Center for Rare Disease Research
    Reverse Translational Research Project
    Platform of Therapeutics for Rare Disease
    Laboratory of Rare Disease Information and Resource Library
    Laboratory of Animal Models for Human Diseases
    Center for Vaccine and Adjuvant Research
    Laboratory of Vaccine Materials
    Laboratory of Regulation of intractable Infectious Diseases
    Laboratory of Immunobiologics Evaluation
    Laboratory of Cell Vaccine
    Laboratory of Mockup Vaccine
    Center for Drug Design Research
    Laboratory of Proteomics for Drug Discovery
    Laboratory of Biopharmaceutical Research
    Laboratory of Antibody Design
    Laboratory of XNA Screening and Design
    Laboratory of Medicinal Plant Screening
    Laboratory of Pharmacokinetic Optimization
    Laboratory of Cell Network Regulation
    Laboratory of Bioimaging and Drug Discovery
    Laboratory of Advanced Biopharmaceuticals
    Laboratory of Clinical and Analytical Chemistry
    Artificial Intelligence Center for Health and Biomedical Research
    Laboratory of Bioinformatics
    Laboratory of In silico design
    AI nutrition project
    Laboratory of Toxicogenomics Informatics
    Laboratory of Proteome Research
    Laboratory of Stem Cell Regulation
    Laboratory of Hepatocyte Regulation
    Laboratory of Cell Cultures
    Section of Laboratory Equipment
    Section of Laboratory Animals
    Research Center for Medicinal Plant Resources
    Tsukuba Primate Research Center
    Laboratory of Infectious Diseases and Immunity
    Laboratory of Nuclear Transport Dynamics
    Laboratory of Gut Environmental System
    KAGAMI Project
    Laboratory of Immunosenescence

    NIHN

    Department of Nutritional Epidemiology and Shokuiku
    Section of the National Health and Nutrition Survey
    Section of Shokuiku
    Section of Dietary Guidelines
    Department of Physical Activity Research
    Section of Behavioral Physiology
    Section of Exercise Guideline
    Section of Healthy Longevity Researches
    Department of Clinical Nutrition
    Section of Nutritional Therapy
    Department of Nutrition and Metabolism
    Section of Chrononutrition
    Section of Energy Metabolism
    Department of Food Function and Labeling
    Section of Food Component Analysis
    Section of Food Safety and Function
    Section of Information Network of Health Food
    International Center for Nutrition and Information
    Section of International Nutrition Strategy
    Section of Population Health Metrics
    Section of Global Disaster Nutrition
    AI Nutrition Research team
    Section of Research Collaboration and Partnership

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