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Home > Research and Activities > Laboratory of Proteome Research

Laboratory of Proteome Research

1. Members

Project leader ADACHI Jun
Senior Research fellow TOMONAGA Takeshi
Senior Researcher MURAOKA Satoshi
Postdoctoral associate NARUMI Ryohei, SATO Yumi, ITO Hisahiro
Researcher ISOYAMA Junko
Technical assistant ISHIDA Mimiko, IKEMOTO Narumi, HIRANO Masayo, TAKADA Yoko, KASUYA Yoko
Collaborative Research Scientist ABE Yuichi, HIRANO Hidekazu, KUGA Takahisa, MATSUBARA Misako, HARA Yasuhiro, SHIROMIZU Takashi
Student GUNJI Daigo
Administrative Assistant HYODO Seiko

2. Background and Aims

Many human diseases are caused by aberrant function of proteins. Therefore, it is obvious that development of novel biomarkers useful for diagnosis and treatment of the diseases needs to find such abnormal proteins. Proteomics is a powerful method to comprehensively analyze such proteins. Recent advances in proteomic technology made it possible to identify disease-related proteins in the clinical samples and thus extensive efforts are now attempted to search for the biomarkers across the country, however, none of them has been accepted for clinical use. The main reason is that candidate proteins for biomarker have not been evaluated if they are really involved in the development and progression of the diseases. In this project, our goal is to identify bona fide biomarkers useful for diagnosis and treatment of human diseases through functional analysis of candidate proteins by combining most recent proteomic technology with molecular and cellular biology.

3. Overview of our research

I. Identification of novel biomarker candidate proteins and peptides

Our project develops and applies methods of MS-based proteomics especially for clinical proteomics. Using patient-derived cell lines, mouse models and clinical samples, we aimed to identify biomarkers whose expressions alter quantitatively and qualitatively along with the development and progression of diseases. Serum and plasma samples and exsomes in these samples are used for the analysis of biomarkers useful for diagnosis, while tissue samples from various lesions are used for identification of target proteins for drug discovery.

II. Evaluation of the candidate proteins and peptides for clinical utility

These biomarker candidate proteins should be validated if they are clinically valuable. Diagnostic utility of the proteins will be evaluated by multicenter clinical trial if they are superior to currently-available biomarkers by themselves or by combination with these widely-used markers. Therapeutic benefit should be evaluated if the function of the proteins participates in the development of diseases. It can be tested by examining the disease-related phenotypes after overexpression or suppression of the candidate proteins in cultured cells or genetically-engineered mice. Validation is also performed using recently developed MRM method with a triple quadrupole mass spectrometer.

Figure 1

Laboratory of Proteome Research

E-mail tomonaga*nibiohn.go.jp (replace * by @)

Research and Activities

  • List

    NIBIO

    Coordination Office of Research Ethics
    Department of Research and Development
    Center for Rare Disease Research
    Reverse Translational Research Project
    Platform of Therapeutics for Rare Disease
    Laboratory of Rare Disease Information and Resource Library
    Laboratory of Animal Models for Human Diseases
    Center for Vaccine and Adjuvant Research
    Laboratory of Vaccine Materials
    Laboratory of Regulation of intractable Infectious Diseases
    Laboratory of Immunobiologics Evaluation
    Laboratory of Cell Vaccine
    Laboratory of Mockup Vaccine
    Center for Drug Design Research
    Laboratory of Proteomics for Drug Discovery
    Laboratory of Biopharmaceutical Research
    Laboratory of Antibody Design
    Laboratory of XNA Screening and Design
    Laboratory of Medicinal Plant Screening
    Laboratory of Pharmacokinetic Optimization
    Laboratory of Cell Network Regulation
    Laboratory of Bioimaging and Drug Discovery
    Laboratory of Advanced Biopharmaceuticals
    Laboratory of Clinical and Analytical Chemistry
    Artificial Intelligence Center for Health and Biomedical Research
    Laboratory of Bioinformatics
    Laboratory of In silico design
    AI nutrition project
    Laboratory of Toxicogenomics Informatics
    Laboratory of Proteome Research
    Laboratory of Stem Cell Regulation
    Laboratory of Hepatocyte Regulation
    Laboratory of Cell Cultures
    Section of Laboratory Equipment
    Section of Laboratory Animals
    Research Center for Medicinal Plant Resources
    Tsukuba Primate Research Center
    Laboratory of Infectious Diseases and Immunity
    Laboratory of Nuclear Transport Dynamics
    Laboratory of Gut Environmental System
    KAGAMI Project
    Laboratory of Immunosenescence

    NIHN

    Department of Nutritional Epidemiology and Shokuiku
    Section of the National Health and Nutrition Survey
    Section of Shokuiku
    Section of Dietary Guidelines
    Department of Physical Activity Research
    Section of Behavioral Physiology
    Section of Exercise Guideline
    Section of Healthy Longevity Researches
    Department of Clinical Nutrition
    Section of Nutritional Therapy
    Department of Nutrition and Metabolism
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    Section of Energy Metabolism
    Department of Food Function and Labeling
    Section of Food Component Analysis
    Section of Food Safety and Function
    Section of Information Network of Health Food
    International Center for Nutrition and Information
    Section of International Nutrition Strategy
    Section of Population Health Metrics
    Section of Global Disaster Nutrition
    AI Nutrition Research team
    Section of Research Collaboration and Partnership

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