1. Members

Project leader	Osamu Suzuki　>>E-mail:osuzuki*nibiohn.go.jp (replace * by @)
Senior researcher	Minako Koura, Kozue Uchio-Yamada
Researcher	Mitsuho Sasaki
Research assistant	Akiko Kawai, Toshiko Tsurumi
Secretary	Hiroko Urahama

2. Background and objectives

A variety of animal models for human diseases play essential roles in the biomedical research including pathogenetic analysis and the development of new drugs for rare and/or incurable diseases. To facilitate the research and development, we are developing new animal models of diseases by establishing spontaneous mutant mice, transplanting human organs or tissues to super SCID mice, and generating gene-modified animals. We are also maintaining, preserving, and providing these model animals and developing related technologies such as reproductive biotechnologies.

3. Overview of our research

I. Development of animal models for human diseases and related technologies

We are developing and establishing new animal models for human diseases focusing on rare and/or incurable diseases including inherited metabolic disorders (e.g., lysosomal storage diseases), intractable nephrosis, cardiomyopathy, and osteoarthrosis. In addition, we are developing and improving the reproductive techniques such as in vitro fertilization and embryo/gamete/ovary cryopreservation in order to maintain/preserve and provide safely/effectively the valuable model animals.

II Development and application of highly sensitive mouse strains for safety evaluation

These mouse strains allow research on (i) multiple diseases, including cancers, malformations, mutations, lethals and others in one individual mouse; (ii) DNA damage and repair; and (iii) efficient detection and analysis of mutations. Transgenerational effects (cancer, malformations, chronic diseases, genomic instability) will be also detectable in the progeny of mice receiving radiation and chemicals.

III Human disease tissues in SCID mice for drug development and safety evaluation

We develop mice that can be transplanted with human organs and tissues (super SCID mice: mice that do not mount an immunological response to transplanted tissues). These mice allows researchers to perform experiments in a system that mimics the conditions in humans and to use these mice as models for drug development and safety research, gene and immune therapies, and human cancer development and metastasis.

Laboratory of Animal Models for Human Diseases

Website	https://animal.nibiohn.go.jp/index.html.en
E-mail	larb*nibiohn.go.jp (replace * by @)