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Home > Research and Activities > Laboratory of Animal Models for Human Diseases

Laboratory of Animal Models for Human Diseases

1. Members

Project leader Osamu Suzuki >>E-mail:osuzuki*nibiohn.go.jp (replace * by @)
Senior researcher Minako Koura, Kozue Uchio-Yamada
Researcher Mitsuho Sasaki
Research assistant Akiko Kawai, Toshiko Tsurumi
Secretary Hiroko Urahama

2. Background and objectives

A variety of animal models for human diseases play essential roles in the biomedical research including pathogenetic analysis and the development of new drugs for rare and/or incurable diseases. To facilitate the research and development, we are developing new animal models of diseases by establishing spontaneous mutant mice, transplanting human organs or tissues to super SCID mice, and generating gene-modified animals. We are also maintaining, preserving, and providing these model animals and developing related technologies such as reproductive biotechnologies.

3. Overview of our research

I. Development of animal models for human diseases and related technologies

We are developing and establishing new animal models for human diseases focusing on rare and/or incurable diseases including inherited metabolic disorders (e.g., lysosomal storage diseases), intractable nephrosis, cardiomyopathy, and osteoarthrosis. In addition, we are developing and improving the reproductive techniques such as in vitro fertilization and embryo/gamete/ovary cryopreservation in order to maintain/preserve and provide safely/effectively the valuable model animals.

Development of animal models for human diseases and related technologies

II Development and application of highly sensitive mouse strains for safety evaluation

These mouse strains allow research on (i) multiple diseases, including cancers, malformations, mutations, lethals and others in one individual mouse; (ii) DNA damage and repair; and (iii) efficient detection and analysis of mutations. Transgenerational effects (cancer, malformations, chronic diseases, genomic instability) will be also detectable in the progeny of mice receiving radiation and chemicals.

Development and application of highly sensitive mouse strains for safety evaluation

III Human disease tissues in SCID mice for drug development and safety evaluation

We develop mice that can be transplanted with human organs and tissues (super SCID mice: mice that do not mount an immunological response to transplanted tissues). These mice allows researchers to perform experiments in a system that mimics the conditions in humans and to use these mice as models for drug development and safety research, gene and immune therapies, and human cancer development and metastasis.

Human disease tissues in SCID mice for drug development and safety evaluation

Laboratory of Animal Models for Human Diseases

Website https://animal.nibiohn.go.jp/index.html.en
E-mail larb*nibiohn.go.jp (replace * by @)

Research and Activities

  • List

    NIBIO

    Coordination Office of Research Ethics
    Department of Research and Development
    Center for Rare Disease Research
    Reverse Translational Research Project
    Platform of Therapeutics for Rare Disease
    Laboratory of Rare Disease Information and Resource Library
    Laboratory of Animal Models for Human Diseases
    Center for Vaccine and Adjuvant Research
    Laboratory of Vaccine Materials
    Laboratory of Regulation of intractable Infectious Diseases
    Laboratory of Immunobiologics Evaluation
    Laboratory of Cell Vaccine
    Laboratory of Mockup Vaccine
    Center for Drug Design Research
    Laboratory of Proteomics for Drug Discovery
    Laboratory of Biopharmaceutical Research
    Laboratory of Antibody Design
    Laboratory of XNA Screening and Design
    Laboratory of Medicinal Plant Screening
    Laboratory of Pharmacokinetic Optimization
    Laboratory of Cell Network Regulation
    Laboratory of Bioimaging and Drug Discovery
    Laboratory of Advanced Biopharmaceuticals
    Laboratory of Clinical and Analytical Chemistry
    Artificial Intelligence Center for Health and Biomedical Research
    Laboratory of Bioinformatics
    Laboratory of In silico design
    AI nutrition project
    Laboratory of Toxicogenomics Informatics
    Laboratory of Proteome Research
    Laboratory of Stem Cell Regulation
    Laboratory of Hepatocyte Regulation
    Laboratory of Cell Cultures
    Section of Laboratory Equipment
    Section of Laboratory Animals
    Research Center for Medicinal Plant Resources
    Tsukuba Primate Research Center
    Laboratory of Infectious Diseases and Immunity
    Laboratory of Nuclear Transport Dynamics
    Laboratory of Gut Environmental System
    KAGAMI Project
    Laboratory of Immunosenescence

    NIHN

    Department of Nutritional Epidemiology and Shokuiku
    Section of the National Health and Nutrition Survey
    Section of Shokuiku
    Section of Dietary Guidelines
    Department of Physical Activity Research
    Section of Behavioral Physiology
    Section of Exercise Guideline
    Section of Healthy Longevity Researches
    Department of Clinical Nutrition
    Section of Nutritional Therapy
    Department of Nutrition and Metabolism
    Section of Chrononutrition
    Section of Energy Metabolism
    Department of Food Function and Labeling
    Section of Food Component Analysis
    Section of Food Safety and Function
    Section of Information Network of Health Food
    International Center for Nutrition and Information
    Section of International Nutrition Strategy
    Section of Population Health Metrics
    Section of Global Disaster Nutrition
    AI Nutrition Research team
    Section of Research Collaboration and Partnership

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