Laboratory of Rare Disease Biospecimen (Rare Disease Bank)
1. Key members
|Project leader||Arihiro Kohara|
|Specially appointed researcher||Makoto Hirata|
|Technical assistant||Mayako Tada, Akiko Hinomura, Sanae Tanaka|
2. Background and objectives
It is important to improve research infrastructures and to plan for research revitalization in order to overcome diseases. To that end, it is essential that we construct a better system where we comprehensively collect and store the valuable biological specimens obtained with patient consent as research resources, and allow those researchers engaged in disease research and drug development research to make broad use of those specimens. The objective of this research is the improvement of the quality of the research resources for diseases, the operation of "Rare Disease Bank" and "Human Tissue Bank" ) that facilitates the distribution of those resources and the provision of rigorously quality-controlled specimens to contribute towards the efficient implementation of research into overcoming diseases.
3. Overview of our research
In order to further promote research into overcoming diseases, we have been operating "Rare Disease Bank", "Human Tissue Bank*", "Japanese B-cells and Genomic DNA Bank*", and "Gene Bank*". (✱ Japan Health Sciences Foundation transferred the business of Health Science Research Resources Bank (HSRRB) to National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) from 2013.)
I. Rare Disease Bank (Only in Japan)
Because the rare intractable diseases have little number of patients, it is difficult to collect specimens to study them. To support the research of rare intractable diseases, we have collected rare intractable disease specimens (DNA, serum, plasma, and cells) and supplied them to researchers. These specimens and information are collected, cooperated by hospitals and research organizations, from Japanese patients under strict ethical guidelines after obtaining informed consent and guaranteeing their anonymity. Specimen storage is conducted under appropriate conditions followed by our standard operation procedures.
II. Human Tissue Bank (Only in Japan)
A human specimen is indispensable to the developmental research of medical science. At present, it is difficult to procure human specimens for research use in Japan. In order to rectify this difficult situation, Human Tissue Bank has been operating a public bank in accordance with strict ethical guidelines. Human Tissue Bank deals with surplus surgical tissues that are not required for histological examination and are usually discarded. These tissues are collected by contracted hospitals after obtaining informed consent from Japanese patients and guaranteeing their anonymity.
III. Japanese B-cells and Genomic DNA Bank (Only in Japan)/ Gene Bank
We offer Japanese EBV transformed B cell lines and their genomic DNAs (derived from about 2,000 donors) for researchers. In particular, resources from healthy donors are useful for the comparison of genetic backgrounds between Japanese disease and healthy groups.
We have carried on the work of the former Gene Bank organization (the BAC clone screening service, DNA clone apportionment, and provision of the integrated Macaca fascicularis cDNA database). Gene Bank provides DNA clones derived from human, mouse, macaque and chimpanzee to researchers in order to promote genome science.
For further information about the previous work, please visit the following sites:
Old Gene Bank web site: http://genebank.nibiohn.go.jp/index_e.html
Macaca fascicularis cDNA database (QFbase): http://genebank.nibiohn.go.jp/qfbase/index.html
Chimpanzee cDNA database (PRIGEN): http://www.prigen.org
Laboratory of Rare Disease Biospecimen (Gene Bank)
To inquire about Gene Bank, please contact:
To inquire about the Rare Disease Bank, please contact: