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20212020201920182017201620152014201320122011201020092008200720062005以前

  2008年度
受賞歴
角田慎一:


阿部康弘:


萱室裕之:




野村鉄也:



日本薬学会薬学研究ビジョン部会賞、癌治療最適化のための細胞内薬物ターゲティング技術の研究.

日本薬学会近畿支部奨励賞、アンタゴニスト活性を有したTNFR1指向性変異体の新規自己免疫疾患治療薬としての有用性評価.

12th International TNF Conference ANRF Travel Award, Identification of new candidates as mucosal vaccine adjuvant in TNF superfamily cytokines.ファーマバイオフォーラム優秀発表者賞、活性増強型TNF変異体の粘膜ワクチンアジュバントへの応用.

ファーマバイオフォーラム優秀発表者賞、新規自己免疫疾患治療薬の開発を目指したTNFR1指向性アンタゴニストの創出.
日本DDS学会ベストポスター賞、アンタゴニスト活性を有するI型受容体指向性
TNF変異体の評価:関節リウマチモデルに対する治療効果および安全性の検討.

原著論文
  鎌田 春彦

Shibata H., Yoshioka Y., Ohkawa A., Minowa K., Mukai Y., Abe Y., Taniai M., Nomura T., Kayamuro H., Nabeshi H., Sugita T., Imai S., Nagano K., Yoshikawa T., Fujita T., Nakagawa S., Yamamoto A., Ohta T., Hayakawa T., Mayumi T., Vandeenabeele P., Aggarwal BB., Nakamura T., Yamagata Y., Tsunoda S., Kamada H., Tsutsumi Y.
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.
J. Biol. Chem., 283:998-1007, 2008. [PubMed]

Sugita T., Yoshikawa T., Mukai Y., Yamanada N., Imai S., Nagano K., Yoshida Y., Shibata H., Yoshioka Y., Nakagawa S., Kamada H., Tsunoda S., Tsutsumi Y.
Comparative Study of the Protein Transduction Domains-Mediated Molecular Transduction.
Br. J. Pharmacol., 153(6):1143-52, 2008. [PubMed]

Abe Y., Yoshikawa T., Kamada H., Shibata H., Nomura T., Minowa K., Kayamuro H., Katayama K., Miyoshi H., Mukai Y., Yoshioka Y., Nakagawa S., Tsunoda S., Tsutsumi Y.
Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity.
J. Immunol. Methods., 335(1-2):71-8, 2008. [PubMed]

Yoshikawa T., Sugita T., Mukai Y., Yamanada N., Nagano K., Nabeshi H., Yoshioka Y., Nakagawa S., Abe Y., Kamada H., Tsunoda S., Tsutsumi Y.
Organelle-targeted delivery of biological macromolecules using the protein transduction domain: Potential applications for peptide aptamer delivery into the nucleus.
J. Mol. Biol., 380(5):777-782, 2008. [PubMed]

Imai S., Mukai Y., Takeda T., Abe Y., Nagano K., Kamada H., Nakagawa S., Tsunoda S., Tsutsumi Y.
The effect of protein properties on display efficiency using the M13 phage display system.
Pharmazie., 63(10):760-764, 2008. [PubMed]

Shibata H., Yoshioka Y., Ohkawa A., Abe Y., Nomura T., Mukai Y., Nakagawa S., Taniai M., Ohta T., Mayumi T., Kamada H., Tsutsumi Y.
The therapeutic effect of TNFR1-selective antagonistic mutant TNF-α in murine hepatitis models.
Cytokine., 44(2):229-233, 2008. [PubMed]

Mukai Y., Shibata H., Nakamura T., Yoshioka Y., Abe Y., Nomura T., Taniai M., Ohta T., Ikemizu S., Nakagawa S., Tsunoda S., Kamada H., Yamagata Y., Tsutsumi Y.
Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant.
J. Mol. Biol., 385:1221?1229, 2009.[PubMed]

永田 諭志
Onda M, Beers R, Xiang L, Nagata S, Wang Q, Pastan I (2008) An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proceedings of National Academy of Sciences of the United States of America 105, 11311-11316.[PubMed]

Matsushita K, Margulies I, Onda M, Nagata S, Stetler-Stevenson M, Kreitman RJ (2008) Soluble CD22 as a tumor marker for hairy cell leukemia. Blood, 112, 2272-2277.[PubMed]

Das S, Hahn Y, Walker D, Nagata S, Willingham MC, Peehl DM, Bera T, Lee B, Pastan I (2008) Topology of NGEP, a prostate specific cell:cell junction protein widely expressed in many cancers of different grade level. Cancer Research, 68, 6306-6312.[PubMed]

Ise T, Das S, Nagata S, Maeda H, Lee Y, Onda M, Anver MR, Bera TK, Pastan I (2008) Expression of POTE protein in human testis detected by novel monoclonal antibodies. Biochemical and Biophysical Research Communications, 365, 603-608.[PubMed]

Du X,* Nagata S,* Ise T, Stetler-Stevenson M and Pastan I (2008) FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia and B-cell non-Hodgkin’s lymphoma as a target of immunotoxins. Blood 111, 338-343. (*equal contribution acknowledged)[PubMed]



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