Information: NIBIO
Anti-IL-8 antibody, Improves Inflammation and Fibrosis in Endometriosis in an Industry-Government-Academia Non-Clinical Study Published in Science Translational Medicine
Feb. 28, 2023
Tsukuba Primate Research Center (Tsukuba city), National Institutes of Biomedical Innovation, Health and Nutrition (hereafter "NIBIOHN") , Chugai Pharmaceutical Co., Ltd. (TOKYO: 4519) and Jichi Medical University Saitama Medical Center (Saitama city) announced that anti-IL-8 antibody under development for the treatment of endometriosis, has been published in the U.S. scientific journal, Science Translational Medicine on February 22, 2023 (local time), with results from nonclinical studies in monkeys showing improvement in inflammation and fibrosis in endometriosis. These nonclinical studies were presented at the 44th annual meeting of the Japan Society of Endometriosis on January 21, 2023, in Kochi city.
The research seeks to understand the pathology of endometriosis, which affects 1 in 10 women in their 20s to 40s and causes pain and infertility. Currently, the standard of care for endometriosis is symptomatic treatment with hormone-related preparations and analgesics.
The results of this nonclinical study suggested that the anti-IL-8 antibody(AMY109) could be a novel therapeutic agent based on the pathology of endometriosis(figure below).
"In cynomolgus monkeys, some animals spontaneously develop endometriosis, but the severity of symptoms varies, making it difficult to produce reliable results only from spontaneous animals. In this nonclinical study, cynomolgus monkeys were successfully produced as a model of endometriosis. Furthermore, it was possible to perform experiments in a population with a homogenous degree of symptoms, suggesting the establishment of a reliable evaluation system and the usefulness of the anti-IL-8 antibody. We hope this study will help as many of those who have endometriosis," said Dr. Tadashi Sankai, D.V.M., Ph.D, Tsukuba Primate Research Center, NIBIOHN.
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