● 2011年業績

Kawabata K., Takayama K., Nagamoto Y., Saldon M.S., Higuchi M., Mizuguchi H. Endodermal and Hepatic Differentiation from Human Embryonic Stem Cells and Human Induced Pluripotent Stem Cells. J. Stem Cell Res., in press.

Inamura M., Kawabata K., Takayama K., Tashiro K., Sakurai F., Katayama K., Toyoda M., Akutsu H., Miyagawa Y., Okita H., Kiyokawa N., Umezawa A., Hayakawa T., Furue MK., Mizuguchi H. Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Mol. Ther., 19: 400-407 (2011)

Takayama K., Inamura M., Kawabata K., Tashiro K., Katayama K., Hayakawa T., Furue MK., Mizuguchi H. Efficient and selective generation of two distinct endoderm lineages from human ES and iPS cells by differentiation stage-specific SOX17 transduction. PLoS One., 6, e21780 (2011)

Sugio K., Sakurai F., Katayama K., Matsui H., Kawabata K., Kawase A., Iwaki M., Hayakawa T., Fujiwara T., Mizuguchi H. Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences. Clin. Cancer Res., 17: 2807-2818 (2011)

Motegi Y., Katayama K., Sakurai F., Kato T., Yamaguchi T., Matsui H., Takahashi M., Kawabata K., Mizuguchi H. An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors. J. Cont. Rel., 153: 149-153 (2011)

Shimizu K., Sakurai F., Machitani M., Katayama K., Mizuguchi H. Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a replication-incompetent adenovirus vector. Mol. Pharmaceutics,in press.

Machitani M., Katayama K., Sakurai F., Matsui H., Yamaguchi T., Suzuki T., Miyoshi H., Kawabata K., Mizuguchi H. Development of an adenovirus vector lacking the expression of virus-associated RNAs. J. Cont. Rel., 154: 285-289 (2011)

Katayama K., Furuki R., Yokoyama H., Kaneko M., Tachibana M., Yoshida I., Nagase H., Tanaka K., Sakurai F., Mizuguchi H., Nakagawa S., Nakanishi T. Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector. Biomaterials., 32: 4185-4193 (2011)

Suzuki-Kouyama E., Katayama K., Sakurai F., Yamaguchi T., Kurachi S., Kawabata K., Nakagawa S., Mizuguchi H. Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction. Biomaterials., 32: 1724-1730 (2011)

Matsui H., Sakurai F., Katayama K., Kurachi S., Tashiro K., Sugio K., Kawabata K., Mizuguchi H. Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob. Virus Res., 155: 48-54 (2011)

Suzuki T., Sasaki T., Yano K., Sakurai F., Kawabata K., Kondoh M., Hayakawa T., Yagi K., Mizuguchi H. Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome. Virus Res., 158: 154-160 (2011)

Iwahori K., Serada S., Fujimoto M., Nomura S., Osaki T., Lee C.M., Mizuguchi H. , Takahashi T., Ripley B., Okumura M., Kawase I., Kishimoto T., Naka T. Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma.Int. J. Cancer., 129, 993-1005 (2011)

Yoshida T., Kondoh M., Ojima M., Mizuguchi H., Yamagishi Y., Sakamoto N., Yagi K. Adenovirus vector-mediated assay system for Hepatitis C virus replication. Nucleic. Acid Res., 39: e64 (2011)

Furukawa N., Sakurai F., Katayama K., Seki N., Kawabata K., Mizuguchi H. Optimization of a microRNA expression vector for function analysis of microRNA. J. Cont. Rel., 150: 94-101 (2011)

Kawashima R., Abei M., Fukuda K., Nakamura K., Murata T., Wakayama M., Seo E., Hasegawa N., Mizuguchi H., Obata Y., Hyodo I., Hamada H., Yokoyama K.K. EpCAM- and EGFR- targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus. Int. J. Cancer., 129: 1244-53 (2011)

Iwata-Kajihara T., Sumimoto H., Kawamura N., Ueda R., Takahashi T., Mizuguchi H., Miyagishi M., Takeda K., Kawakami Y. Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors. J. Immunol., 187: 27-36 (2011)

Yao X., Yoshioka Y., Morishige T., Eto Y., Narimatsu S., Kawai Y., Mizuguchi H., Gao J.Q., Mukai Y., Okada N., Nakagawa S. Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy. Mol. Ther, in press.

Machitani M., Yamaguchi T., Shimizu K., Sakurai F., Katayama K., Kawabata K., Mizuguchi H. Adenovirus vector-derived VA-RNA-mediated innate immune responses. Pharmaceutics., 3: 338-353 (2011)

Sakurai F., Katayama K., Mizuguchi H. MicroRNA-regulated transgene expression system for gene therapy and virotherapy. Frontier in Bioscience. , 17: 2389-2401 (2011)

Tashiro K. Optimization of adenovirus vectors for transduction in embryonic stem cells and induced pluripotent stem cells. Yakugaku Zasshi., 131: 1333-1338(2011)

松井勇人、櫻井文教、形山和史、水口裕之；改良型アデノウイルスベクターの開発と神経系細胞への遺伝子導入、日本薬理学会雑誌、137、70-74 (2011)

水口裕之、櫻井文教；ウイルスベクターと遺伝子治療、化学療法の領域、印刷中

稲村充、高山和雄、川端健二、水口裕之；ヒトES/iPS細胞から肝細胞への高効率分化誘導と毒性評価系への応用、生産と技術、印刷中

高山和雄、川端健二、水口裕之；多能性幹細胞から肝細胞への分化誘導、再生医療業書、印刷中

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