● 業績 （過去３年間）

当研究室の業績一覧へリンクします。

2014年・ 2013年・ 2012年・ 2011年

● 2014年業績

Hemmi M, Tachibana M, Tsuzuki S, Shoji M, Sakurai F, Kawabata K, Kobiyama K, Ishii KJ, Akira S, Mizuguchi H. The Early Activation of CD8(+) T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector.Biomed Res Int., in press

Nagamoto Y, Takayama K, Tashiro K, Tateno C, Sakurai F, Tachibana M, Kawabata K, Ikeda K, Tanaka Y, Mizuguchi H. Efficient engraftmentof human iPS cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xLmutant gene.Cell Transplant., in press

Watanabe H, Takayama K, Inamura M, Tachibana M, Mimura N, Katayama K, Tashiro K, Nagamoto Y, Sakurai F, Kawabata K, Furue MK, Mizuguchi H. HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin. PLoS One., 9, e90791 (2014)

Tashiro K., Nonaka A., Hirata N., Yamaguchi T., Mizuguchi H., Kawabata K. Plasma Elevation of Vascular Endothelial Growth Factor Leads to the Reduction of Mouse Hematopoietic and Mesenchymal Stem/Progenitor Cells in the Bone Marrow.Stem Cells Dev., in press.

Taura A, Furuta K, Yamaguchi T, Kawabata K, Tanaka S. Regulation of histamine synthesis and tryptase expression through transcription factors, Gfi1 and Gfi1b, in murine cultured mast cells. Biol. Pharm. Bull., 37, 81-86 (2014)

● 2013年業績

Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K, Mizuguchi H. Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes.Stem Cell Reports, 1, 322-335 (2013)

Takayama K, Kawabata K, Inamura M, Ohashi K, Nagamoto Y, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Furue-Kusuda M, Mizuguchi H. CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determine the hepatoblast fate decision.Development, in press.

Matsuura M, Somboonthum P, Murakami K, Ota M, Shoji M, Kawabata K, Mizuguchi H, Gomi Y, Yamanishi K, Mori Y. Novel polyvalent live vaccine against varicella-zoster and mumps virus infections.Microbiol Immunol., 57, 704-714 (2013)

山口朋子、川端健二； ｉＰＳ細胞由来マスト細胞を用いた難治性疾患の新規治療薬開発へ向けて、Biophilia、Vol.2 No.3、21-25 (2013)

Takayama K., Kawabata K., Nagamoto Y., Kishimoto K., Tashiro K., Sakurai F., Tachibana M., Kanda K., Hayakawa T., Furue MK., Mizuguchi H. 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials, 34: 1781-1789 (2013)

Yamaguchi T., Tashiro K., Tanaka S., Katayama S., Ishida W., Fukuda K., Fukushima A., Araki R., Abe M., Mizuguchi H., Kawabata K. Two-step differentiation of mast cells from induced pluripotent stem cells. Stem Cells Dev., 22: 726-734 (2013)

● 2012年業績

Kawabata K, Takayama K, Nagamoto Y, Saldon MM, Higuchi M, Mizuguchi H. Endodermal and hepatic differentiation from human embryonic stem cells and human induced pluripotent stem cells. J. Stem Cell Res. Ther., S10, 002　(2012)

Bennett D, Sakurai F, Shimizu K, Matsui H, Tomita K, Suzuki T, Katayama K, Kawabata K, Mizuguchi H. Further Reduction in Adenovirus Vector-Mediated Liver Transduction without Largely Affecting Transgene Expression in Target Organ by Exploiting MicroRNA-Mediated Regulation and the Cre-loxP Recombination System. Mol Pharm., in press.

Shoji M., Katayama K., Tachibana M., Tomita K., Sakurai F., Kawabata K., Mizuguchi H. Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments. Vaccine, 30: 7278-7285 (2012)

Shoji M., Tachibana M., Katayama K., Tomita K., Tsuzuki S., Sakurai F., Kawabata K., Ishii KJ., Akira S., Mizuguchi H. Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa. Biochem. Biophys. Res. Commun., 425: 89-93 (2012)

Tashiro K., Omori M., Kawabata K., Hirata N., Yamaguchi T., Sakurai F., Takaki S., Mizuguchi H. Inhibition of Lnk in Mouse Induced Pluripotent Stem Cells Promotes Hematopoietic Cell Generation.Stem Cells Dev., 21: 3381-3390 (2012)

Takayama K., Inamura M., Kawabata K., Sugawara M., Kikuchi K., Higuchi M., Nagamoto Y., Watanabe H., Tashiro K., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H.　 Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. J. Hepatol, 57: 628-636 (2012)

Nagamoto Y., Tashiro K., Takayama K., Ohashi K., Kawabata K., Sakurai F., Tachibana M., Hayakawa T., Furue MK., Mizuguchi H.　 The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets. Biomaterials, 33: 4526-4534 (2012)

Kawabata K, Inamura M, Mizuguchi H.　 Efficient hepatic differentiation from human iPS cells by gene transfer. Methods Mol. Biol., 826, 115-124 (2012)

Tashiro K., Kawabata K., Omori M., Yamaguchi T., Sakurai F., Katayama K., Hayakawa T., Mizuguchi H. Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction. Stem Cell Res., 8: 300-311 (2012)

Takayama K., Inamura M., Kawabata K., Katayama K., Higuchi M., Tashiro K., Nonaka A., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H. Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Mol. Ther., 20: 127-137 (2012)

Iguchi K., Sakurai F., Tomita K., Katayama K., Yamaguchi T., Kawabata K., Tagawa M., Kawabata M., Shirakawa T., Mizuguchi H. Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells. Cancer Gene Ther, 19: 118-125 (2012)

Kawabata K., Inamura M., Mizuguchi H. Efficient hepatic differentiation from human iPS cells by gene transfer. Methods Mol Biol. , 826: 115-124 (2012)

松井勇人、櫻井文教、形山和史、水口裕之；改良型アデノウイルスベクターの開発と神経系細胞への遺伝子導入、日本薬理学会雑誌、137、70-74 (2011)

水口裕之、櫻井文教；ウイルスベクターと遺伝子治療、化学療法の領域、印刷中

稲村充、高山和雄、川端健二、水口裕之；ヒトES/iPS細胞から肝細胞への高効率分化誘導と毒性評価系への応用、生産と技術、印刷中