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研究成果

衣笠泰葉、西野泰子、Mara Anais Llamas-Covarrubias他. 新型コロナウイルス感染症の重症化予測AIモデル. 人工呼吸. 2023, web選考公開.

Kashima Y, Kaneko K, Reteng P, et al. Intensive single-cell analysis reveals immune-cell diversity among healthy individuals. Life Sci Alliance. 2022, 5(7), e202201398.

Imai Y. Dynamics of Higher-Order Chromatin Structure in Response to Viral Infection and its Potential for Treatment of Infectious Diseases. Journal of Infectious Diseases & Therapy. 2022, 10(4), 1000506.

Minato T, Yamaguchi T, Hoshizaki M, et al. ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury. PLoS One. 2022 Jul 22;17(7):e0270920.

Shiimori M, Nukiwa R, Imai Y. Dynamics of the host chromatin three- dimensional response to influenza virus infection. Int Immunol. 2021, 33(10), 541-545.

Siswanto S, Yamamoto H, Furuta H, et al. Drug Repurposing Prediction and Validation From Clinical Big Data for the Effective Treatment of Interstitial Lung Disease. Front Pharmacol. 2021, 12, 635293.

Yamaguchi T, Hoshizaki M, Minato T, et al. ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury. Nat Commun. 2021, 12(1), 6791. 12492-12501.

Shiimori M, Nukiwa R ,Imai Y. Dynamics of the hostchromatin three-dimensional response to influenza virus infection. Int Immunol. 2021 Sep 25;33(10):541-545.

Shiimori M, Ichida Y, Nukiwa R, et al. Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation. iScience. 24(6):102660. 2021 May 29

Nagaki Y, Motoyama S, Yamaguchi T, et al. m6 A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis. Genes Cells. 25(8):547-561. 2020 Aug. Epub 2020 Jul 1

Ogawa M, Ishihara T, Isobe Y, et al. Eosinophils promote corneal wound healing via the 12/15-lipoxygenase pathway. FASEB J. 2020, 34(9), 12492-12501.

Sato T, Shimizu T, Fujita H, et al. GLP-1 Receptor Signaling Differentially Modifies the Outcomes of Sterile vs Viral Pulmonary Inflammation in Male Mice. Endocrinology. 161(12):bqaa201. 2020 Dec 1

Minato T, Nirasawa S, Sato T, et al. B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Nature Communications. 2020 Feb 26

Momota M, Lelliott P, Kubo A, et al. ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity. Int Immunol. 2020 Mar 7 (Epub 2019 Oct 20)

Sato T, Kadowaki A, Suzuki T, et al. Loss of Apelin Augments Angiotensin II-Induced Cardiac Dysfunction and Pathological Remodeling. Int J Mol Sci. 2019, 20(2).12492-12501.

Koizumi Y, Fukushima J, Kobayashi Y, et al. Genome-Scale CRISPR/Cas9 Screening Reveals SqualeneEpoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1. Chembiochem. 2019 Jun 14 (Epub 2019 Apr 18)

Fujiwara S, Hoshizaki M, Ichida Y, et al. Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. Nature Microbiology. 2019 Feb 4 (Epub 2018 Nov 19)

Sato T, Kadowaki A, Suzuki T, et al. Loss of Apelin Augments Angiotensin II-Induced Cardiac Dysfunction and Pathological Remodeling. Int J Mol Sci. 2019 Jan 9

Yamaguchi T, Suzuki T, Sato T,et al. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 2018 Feb 6;11(516).pii: eaan3638.

Rodríguez-Gil A, Ritter O, Saul VV, et al. The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. Sci Rep. 2017 Jun 14; 7(1):3547.

Sato T, Sato C, Kadowaki A, et al. ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.Cardiovasc Res. 2017 Jun 1; 113(7):760-769.

Tanaka KI, Tamura F, Sugizaki T, et al. Evaluation of Lecithinized Superoxide Dismutase for the Prevention of Acute Respiratory Distress Syndrome in Animal Models.Am J Respir Cell Mol Biol. 2017 Feb;56(2):179-190.

Yang CY, Ramamoorthy S, Boller S, et al. Interaction of CCR4-NOT with EBF1 regulatesgene-specific transcription and mRNA stability in B lymphopoiesis. Genes Dev. 2016 Oct 15;30(20):2310-2324. Epub 2016 Nov 2.

Blank T, Detje CN, Spieß A, et al. Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment. Immunity. 2016 Apr 19;44(4):901-12.

Imai Y, Sakuma S, Imai H, et al. Potential cellular targets for anti-influenza drug development. Cellular immunology and immunotherapies. Inpress.

Katahira J, Dimitrova L, Imai Y, et al. NTF2-like domain of Tap plays a critical role in cargo mRNA recognition and export. Nucleic Acids Res. 2015 Feb 18;43(3):1894-904.

Imai Y. Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection. Biochim Biophys Acta. 2015 Apr;1851(4):496-502.

Morita M, Kuba K, Ichikawa A, et al. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell. 2013 Mar 28;153(1):112-25.

Sato T, Suzuki T, Watanabe H, et al. Apelin is a positive regulator of ACE2 in failing hearts. J Clin Invest. 2013 Dec;123(12):5203-11.

Ichikawa A, Kuba K, Morita M, et al. CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin.Am J Respir Crit Care Med. 2013 Jan 1;187(1):65-77.

Neely G, Kuba K, Cammarato A, et al. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 2010, 141(1):142-153.

Imai Y, Kuba K, Neely GG, et al. Identification of oxidative stress and toll like receptor 4 signaling as a key pathway of acute lung injury. Cell. 2008, 18;133(2):235-49.

Imai Y, Kuba K, Rao S, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005 Jul 7;436(7047):112-6.

Kuba K, Imai Y, Rao S, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005 Aug;11(8):875-9.

Göggel R, Winoto-Morbach S, Vielhaber G, et al. PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med. 2004 Feb;10(2):155-60.

Imai Y, Parodo J, Kajikawa O, et al. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA. 2003 Apr 23-30;289(16):2104-12.