Challenging the Time Limit of Life

Our goal at the Immunosenescence Project is
to solve the mystery of immunosenescence, a process that affects all of us.
Our mission is to restore and protect the health of all individuals, from the young to the old.


Updated news/members etc.
Updated news/members etc.
Dr. Yamamoto attended a press conference in FCCJ, entitiled "Developing next-generation vaccines for COVID-19 and beyond", with collaborators. The presentation and Q&A are on FCCJ YouTube channel.
Dr.Nogimori gave a presentation at 5th Workshop on Theoretical Immunology.
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Discovery of new immune factors and research in pursuit of new therapies

We aim to discover new immune factors involved in infectious diseases and cancers, and then develop novel vaccines and/or treatments to fight against them. In particular, we focus on translational research based on the phenomenon of “aging-associated immunosenescence.” Because many reports have shown that elderly patients with advanced immunosenescence are at greater risk of developing cancers or infectious diseases and cannot be treated as effectively using immunotherapies or vaccines.

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Work 1

Research aimed at understanding aging-associated immunosenescence

1. Elucidating the mechanisms of immunosenescence

2. Searching for biomarkers of immunosenescence using a human clinical specimens and primate model

We are currently involved in translational research on the immunosenescence phenomenon using cut-ting-edge immune cell analysis techniques in primate-model monkeys, with which we can achieve very close approximations of human clinical samples and of the immunosenescence phenomenon itself.

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Work 2

Drug/Vaccine discovery research based on our understanding of aging-associated immunosenescence

◆ Infectious disease-related work

1. Development of immunotherapies for the radical cure of AIDS

2. Development of a universal influenza vaccine

3. Development of COVID-19 vaccine

4. Establishment of a mRNA/saRNA vaccine platform

5. Identification of surrogate markers for the prediction of HTLV-1-related diseases

◆ Cancer-related work

1. Development of immunotherapies for intractable cancers, including pancreatic cancer

2. Immunological research on the hepatitis B virus that aims to make a functional cure possible

3. Development of new immunotherapies for the melanoma

By comparing animal (primate-model monkey) and human clinical samples side-by-side, we aim to develop an immunological analysis system directly tied to clinical applications in humans, search for biomarkers, and establish novel protective and curative therapies.

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Selected Publication

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We aim to discover new immune factors for protection against and treatment of infectious diseases and cancer through the analysis of human clinical samples in our laboratory and to apply these findings in the development of novel vaccines and therapies. Given the rapidly aging populace of Japan, we believe that advancing translational research into aging-associated immunosenescence is important. Research has shown that advanced immunosenescence in elderly individuals increases their risks of developing cancers or in-fectious diseases. Furthermore, many different kinds of vaccines against infectious diseases, such as the influenza vaccine, have been shown to be often ineffective in elderly patients with immunosenescence. Therefore, we are currently focused on drug/vaccine discovery research in immunosenescence, using cut-ting-edge immune cell analysis techniques in primate-model monkeys, which help to achieve very close approximations of human clinical samples and the immunosenescence phenomenon. Further, we aim to develop an immunological analysis system for direct clinical application in humans, search for biomarkers, and establish novel protective and curative therapies by comparing animal (primate-model monkey) and human clinical samples.

Our laboratory is currently looking for postdocs, graduate students, technical assistants, collaborators, and individuals for a variety of roles. Dr. Yamamoto, our project leader, is also a Guest Professor at the Osaka University Graduate School of Pharmaceutical Sciences. Through the graduate school collaboration system, we are able to accept graduate students into our laboratory (for more information, click here

Project LeaderTakuya Yamamoto



Project Leader
Takuya Yamamoto
Senior Research Fellow
Shokichi Takahama, Ayaka Washizaki
JSPS Research Fellow
Takuto Nogimori
Postdoctoral Fellow
Ayae Nishiyama, Yuji Masuta, Buluke
Guest Professor/Associated Professor
Hirofumi Akita, Chiyomi Kubo, Yorifumi Satou, Yoshimasa Takahashi, Satoshi Tanaka, Masaya Baba, Hiromi Matsuoka, Yasuko Yokota, Sachiyo Yoshio, Yasuo Yoshioka, Rei Watanabe, Victor Appay
Collaborative Researcher
Mariko Ikuo, Ryo Katube, Hiroyuki Kayo, Ion Shibasaki, Yuko Sugawara, Toshiko Hara, Masaya Higashiguchi, Chiharu Fujiwara Hirotomo Murakami
Technical Staff
Mami Ikeda, Mika Yagoto, Yuki Katayama
Nozomi Higashi
PhD Student
Yuta Nagatsuka, Teerachate Nantakeeratipat


NIH NIAID Vaccine Research Center
Department of Microbiology, Immunology & Tropical Medicine, The George Washington University
Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Université, INSERM U1135
Université de Bordeaux, CNRS UMR5164, INSERM ERL1303, ImmunoConcEpT
Tsukuba Primate Research Center, NIBIOHN
National Institute of Infectious Diseases
The Research Center for Hepatitis and Immunology, The National Center for Global Health and Medicine
The Institute of Medical Science, The University Of Tokyo
School of Health Sciences, Tokyo University of Technology
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
The Research Institute for Microbial Diseases, Osaka University
Department of Gastroenterological Surgery, Osaka International Cancer Institute
Department of Gastroenterological Surgery, Osaka General Medical Center
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
Joint Research Center for Human Retrovirus Infection, Kumamoto University
The International Research Center for Medical Sciences (IRCMS), Kumamoto University
Hokkaido Information University
Several pharmaceutical companies
Nippon Becton Dickinson Company, Ltd.
VLP Therapeutics



We are always recruiting researchers and students who work together with us. If you are interested in, please contact directly.







National Institutes of Biomedical Innovation, Health and Nutrition Center for Vaccine & Adjuvant Research Laboratory of Immunosenescence

7-6-8, Saito-Asagi, Ibaraki City, Osaka 567-0085, Japan/p>

(+81)72-641-9811 (main phone number)