Nakagawa N, Kimura T, Sakate R, Isaka Y, Narita I: Demographics and treatment of patients with primary membranoproliferative glomerulonephritis in Japan using a national registry of clinical personal records. Clinical Experimental Nephrology, 2023 online.
75
Kimura T, Sakai S, Isaka Y: D-Serine as a sensor and effector of the kidney. Clinical Experimental Nephrology, 2023 online.
74
Tanabe M, Sakate R, Nakabayashi J, Tsumura K, Ohira S, Iwato K, Kimura T: A novel in silico scaffold-hopping method for drug repositioning in rare and intractable diseases. bioRxiv, 2023 https://www.biorxiv.org/content/10.1101/2023.07.03.547598v1.
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Tsukamoto Y, Nakamura Y, Hirata M, Okuzaki D, Sakate R, Kimura T: GCN2 kinase-mediated upregulation of ubiquitin C maintains intracellular glutamine level and tRNA(Gln) (CUG) charging under amino acid starvation. FEBS Lett, 2023 10.1002/1873-3468.14628.
72
Taniguchi A, Kawamura M, Sakai S, Kimura-Ohba S, Tanaka Y, Fukae S, Tanaka R, Nakazawa S, Yamanaka K, Horio M, Takahara S, Nonomura N, Isaka Y, Imamura R, Kimura T: d-Asparagine is an ideal endogenous molecule for measuring the glomerular filtration rate. Kidney International Reports, 2023 doi:10.1016/j.ekir.2023.03.009. Online.
71
Kimura T, Ikeuchi H, Yoshino M, Sakate R, Maruyama S, Narita I, Hiromura K: Profiling of kidney involvement in systemic lupus erythematosus by deep learning using the National Database of Designated Incurable Diseases of Japan. Clin Exp Nephrol, 2023 doi:10.1007/s10157-023-02337-x. online.
70
Kimura-Ohba S, Takabatake Y, Takahashi A, Tanaka Y, Sakai S, Isaka Y, Kimura T: Blood levels of d-amino acids reflect the clinical course of COVID-19. Biochemistry and Biophysics Reports. 34, 101452, 2023.
69
Kimura-Ohba S, Asaka MN, Utsumi D, Takabatake Y, Takahashi A, Yasutomi Y, Isaka Y, Kimura T: D-Alanine as a biomarker and a therapeutic option for severe influenza virus infection and COVID-19. Biochim Biophys Acta Mol Basis Dis. 2022 Oct 21;1869(1):166584.
68
Tsukamoto Y, Nakamura Y, Hirata M, Sakate R, Kimura T: i-tRAP (individual tRNA acylation PCR): A convenient method for selective quantification of tRNA charging. RNA. 2022 Oct 25: rna.079323.122. doi: 10.1261/rna.079323.122. Online ahead of print.
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Isaka Y, Yoshiya T, Ono C, Uchiyama A, Hirata H, Hamaguchi S, Kutsuna S, Takabatake Y, Saita R, Yamada T, Takahashi A, Yamato M, Nohara Y, Tsuda S, Anzai I, Kimura T, Takeda Y, Tomono K, Matsuura Y: Establishment and clinical application of SARS-CoV-2 catch column. Clin Exp Nephrol. Nov 7:1-9. 2022 doi: 10.1007/s10157-022-02296-9. Online ahead of print.
66
Kimura T, Yamamoto R, Yoshino M, Sakate R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Nagai K, Yamagata K, Yasuda H, Ichida S, Naruse T, Nishino T, Sobajima H, Akahori T, Ito T, Terada Y, Katafuchi R, Fujimoto S, Okada H, Mimura T, Suzuki S, Saka Y, Sofue T, Kitagawa K, Fujita Y, Mizutani M, Kashihara N, Sato H, Narita I and Isaka Y: Deep learning analysis of clinical course of primary nephrotic syndrome: Japan Nephrotic Syndrome Cohort Study (JNSCS). Clinical and Experimental Nephrology. Published online 12 August 2022
65
Jingushi K, Kawashima A, Saito T, Kanazawa T, Motooka D, Kimura T, Mita M, Yamamoto A, Uemura T, Yamamichi G, Okada K, Tomiyama E, Koh Y, Matsushita M, Kato T, Hatano K, Uemura M, Tsujikawa K, Wada H, Nonomura N.: Circulating extracellular vesicles carrying Firmicutes reflective of the local immune status may predict clinical response to pembrolizumab in urothelial carcinoma patients. Cancer Immunol Immunother. 2022 May 22. doi: 10.1007/s00262-022-03213-5. Online ahead of print. PMID: 35598195
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Sakate R, Kimura T: Drug repositioning trends in rare and intractable diseases. Drug Discovery Today 2022. in press
63
Kawamura M, Hesaka A, Taniguchi A, Nakazawa S, Abe T, Hirata M, Sakate R, Horio M, Takahara S, Nonomura N, Isaka Y, Imamura R, Kimura T: Measurement of glomerular filtration rate using endogenous d-serine clearance in living kidney transplant donors and recipients. EClinicalMedicine. 43, 101223, 2022.
62
Iwata Y, Okushima H, Hesaka A, Kawamura M, Imamura R, Takahara S, Horio M, Tanaka Y, Ikeda T, Nakane M, Mita M, Hayashi T, Isaka Y, Kimura T: Identification of diabetic nephropathy in patients undergoing kidney biopsy through blood and urinary profiles of D-serine. Kidney360. 2 (11) 1734-1742, 2021.
61
Hesaka A, Tsukamoto Y, Nada S, Kawamura M, Ichimaru N, Sakai S, Nakane M, Mita M, Okuzaki D, Okada M, Isaka Y, Kimura T: D-Serine mediates cellular proliferation for kidney remodeling. Kidney360. 2(10), 1611-1624, 2021.
60
Sakate R, Kimura T: Drug target gene-based analyses of drug repositionability in rare and intractable diseases. Sci Rep. 11(1):12338, 2021.
59
Okushima H, Iwata Y, Hesaka A, Sugimori E, Ikeda T, Nakane M, Mita M, Hayashi T, Isaka Y, Kimura T: Intra-body dynamics of D-serine reflects the origin of kidney diseases. Clinical and Experimental Nephrology. 25(8):893-901, 2021.
58
Klionsky D et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. Feb 8:1-382, 2021.
57
Watanabe M, Nakamura Y, Sato S, Niino M, Fukaura H, Tanaka M, Ochi H, Kanda T, Takeshita Y, Yokota T, Nishida Y, Matsui M, Nagayama S, Kusunoki S, Miyamoto K, Mizuno M, Kawachi I, Saji E, Ohashi T, Shimohama S, Hisahara S, Nishiyama K, Iizuka T, Nakatsuji Y, Okuno T, Ochi K, Suzumura A, Yamamoto K, Kawano Y, Tsuji S, Hirata M, Sakate R, Kimura T, Shimizu Y, Nagaishi A, Okada K, Hayashi F, Sakoda A, Masaki K, Shinoda K, Isobe N, Matsushita T, Kira JI: HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data. Sci Rep. 11(1):607, 2021.
56
Kimura T: Utility of d-serine monitoring in kidney disease. BBA proteins and proteomics 1868(9): 140449, 2020
55
Kimura T, Hesaka A,Isaka Y: D-Amino acids and kidney diseases. Clinical and Experimental Nephrology 24(5): 404-410, 2020
54
Yamamoto T, Takabatake Y, Minami S, Sakai S, Fujimura R, Takahashi A, Namba-Hamano T, Matsuda J, Kimura T, Matsui I, Kaimori JY, Takeda H, Takahashi M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Isaka Y: Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux.Autophagy.Jun 28：1-14,2020
53
Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, Fujimura R, Namba-Hamano T, Yonishi H, Nakamura J, Kimura T, Kaimori J-Y, Matsui I, Takahashi M, Nakao M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Yoshimori T, Isaka Y: Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.Autophagy.Oct;16(10)1889-1904,2020
52
Hesaka A, Yasuda K, Sakai S, Yonishi H, Namba-Hamano T, Takahashi A, Mizui M, Hamase K, Matsui R, Mita M, Horio M, Isaka Y, Kimura T: Dynamics of D-serine reflected the recovery course of a patient with rapidly progressive glomerulonephritis. CEN Case Rep. 8(4): 297-300, 2019
51
Hesaka A, Sakai S, Hamase K, Ikeda T, Matsui R, Mita M, Horio M, Isaka Y, Kimura T: D-Serine reflects kidney function and diseases. Sci Rep 9: 5104, 2019
50
Kimura T: Reverse translational research of autophagy and metabolism in kidney disease -Oshima Award Address 2018. Clin Exp Nephrol. 23(6): 733-738, 2019
49
Furusho A, Koga R, Akita T, Mita M, Kimura T, Hamase K. Three-Dimensional High-Performance Liquid Chromatographic Determination of Asn, Ser, Ala, and Pro Enantiomers in the Plasma of Patients with Chronic Kidney Disease. Anal Chem. 91:11569, 2019
48
Matsuda J, Namba T, Takabatake Y, Kimura T, Takahashi A, Yamamoto T, Minami S, Sakai S, Fujimura R, Kaimori JY, Matsui I, Hamano T, Fukushima Y, Matsui K, Soga T, Isaka Y: Antioxidant Role of Autophagy in Maintaining the Integrity of Glomerular Capillaries. Autophagy 14: 53-65, 2018
47
Hayashi T, Yasuda K, Kimura T, Sasaki K, Shimada K, Hashimoto N, Isaka Y: Prognostic Significance of Asymptomatic Brain Natriuretic Peptide Elevation at Nephrology Referral in Patients with Chronic Kidney Disease. Am J Nephrol 48: 205-213, 2018
46
Takahashi A, Takabatake Y, Kimura T, Maejima I, Namba T, Yamamoto T, Matsuda J, Minami S, Kaimori JY, Matsui I, Matsusaka T, Niimura F, Yoshimori T, Isaka Y: Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules. Diabetes 66: 1359-1372, 2017
Yamamoto T, Takabatake Y, Takahashi A, Kimura T, Namba T, Matsuda J, Minami S, Kaimori JY, Matsui I, Matsusaka T, Niimura F, Yanagita M, Isaka Y: High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney. J Am Soc Nephrol 28: 1534-1551, 2017
43
Minami S, Yamamoto T, Takabatake Y, Takahashi A, Namba T, Matsuda J, Kimura T, Kaimori JY, Matsui I, Hamano T, Takeda H, Takahashi M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Isaka Y: Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation. Autophagy 13: 1629-1647, 2017
42
Kimura T, Jia J, Claude-Taupin A, Kumar S, Choi SW, Gu Y, Mudd M, Dupont N, Jiang S, Peters R, Farzam F, Jain A, Lidke KA, Adams CM, Johansen T, Deretic V: Cellular and molecular mechanism for secretory autophagy. Autophagy 13: 1084-1085, 2017
41
Kimura T, Jia J, Kumar S, Choi SW, Gu Y, Mudd M, Dupont N, Jiang S, Peters R, Farzam F, Jain A, Lidke KA, Adams CM, Johansen T, Deretic V: Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy. EMBO J 36: 42-60, 2017
40
Kimura T, Isaka Y, Yoshimori T: Autophagy and kidney inflammation. Autophagy 13: 997-1003, 2017
39
Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd M, Kimura T, Choi S, Peters R, Mandell M, Bruun J, Johansen T, Deretic V: TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Dev Cell 39: 1-15, 2016
38
Yamamoto T, Takabatake Y, Kimura T, Takahashi A, Namba T, Matsuda J, Minami S, Kaimori JY, Matsui I, Kitamura H, Matsusaka T, Niimura F, Yanagita M, Isaka Y, Rakugi H: Time-dependent dysregulation of autophagy: implications in aging and mitochondrial homeostasis in the kidney proximal tubule. Autophagy 12: 801, 2016
37
Klionsky D et al: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12: 1-222, 2016
36
Hayashi T, Kimura T, Yasuda K, Sasaki K, Obi Y, Nagayama H, Ohno M, Uematsu K, Tamai T, Nishide T, Rakugi H, Isaka Y: Early Nephrology Referral 6 Months Before Dialysis Initiation Can Reduce Early Death But Does Not Improve Long-Term Cardiovascular Outcome on Dialysis. Circ J 80: 1008-1016, 2016
35
Kimura-Ohba S, Yang Y, Thompson J, Kimura T, Salayandia VM, Cosse M, Yang Y, Sillerud LO, Rosenberg GA: Transient increase of fractional anisotropy in reversible vasogenic edema. J Cereb Blood Flow Metab 36: 1731-1743, 2016
34
Sasaki K, Mizuno H, Iwamoto N, Imakita M, Yasuda K, Kimura T, Rakugi H, Isaka Y, Hayashi T: Laparoscopy Reveals a Diversity of Peritoneal Change in Patients with Long-Term Vintage of Peritoneal Dialysis. Blood Purif 41: 48-54, 2016
33
Kimura T, Mandell M, Deretic V: Precision autophagy directed by receptor regulators - emerging examples within the TRIM family. J Cell Sci 129: 881-891, 2016
32
Kimura T, Yasuda K, Yamamoto R, Soga T, Rakugi H, Hayashi T, Isaka Y: Identification of biomarkers for development of end-stage kidney disease in chronic kidney disease by metabolomic profiling. Scientific Reports 6: 26138, 2016
31
Kimura T, Hamase K, Miyoshi Y, Yamamoto R, Yasuda K, Mita M, Rakugi H, Hayashi T, Isaka Y: Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease. Scientific Reports 6: 26137, 2016
Namba T, Takabatake Y, Kimura T, Takahashi A, Yamamoto T, Matsuda J, Kitamura H, Niimura F, Matsusaka T, Iwatani H, Matsui I, Kaimori J, Kioka H, Isaka Y, Rakugi H: Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis. J Am Soc Nephrol 25: 2254-2266, 2014
25
Takabatake Y, Kimura T, Takahashi A, Isaka Y: Autophagy and the kidney: health and disease. Nephrol Dial Transplant 29: 1639-1647, 2014
24
Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, Munch J, Kirchhoff F, Simonsen A, Wei Y, Levine B, Johansen T, Deretic V: TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev Cell 30: 394-409, 2014
23
Mandell MA, Kimura T, Jain A, Johansen T, Deretic V: TRIM proteins regulate autophagy: TRIM5 is a selective autophagy receptor mediating HIV-1 restriction. Autophagy 10: 2387-2388, 2014
Kimura T, Takabatake Y, Takahashi A, Isaka Y. Chloroquine in cancer therapy: a double-edged sword of autophagy. Cancer Res. Vol 73; 2013:3-7.
20
Maejima I, Takahashi A, Omori H, Kimura T, Takabatake Y, Saitoh T, Yamamoto A, Hamasaki M, Noda T, Isaka Y, Yoshimori T: Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury. EMBO J 32: 2336-2347, 2013
19
Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y, Rakugi H: Autophagy guards against Cisplatin-induced acute kidney injury. Am J Pathol 180: 517-525, 2012
18
Yasuda K, Kimura T, Sasaki K, Obi Y, Iio K, Yamato M, Rakugi H, Isaka Y, Hayashi T: Plasma B-type natriuretic peptide level predicts kidney prognosis in patients with predialysis chronic kidney disease. Nephrol Dial Transplant 27: 3885-3891, 2012
17
Hayashi T, Kimura T, Yasuda K, Obi Y, Sasaki K, Iio K, Miyasato K, Kamimura T, Kitamura H, Tsubakihara Y, Rakugi H, Isaka Y: Prognostic significance of left ventricular hypertrophy observed at dialysis initiation depends on the pre-dialysis use of erythropoiesis-stimulating agents. Clin Exp Nephrol 17: 294-303, 2012
16
Kimura T, Yasuda K, Obi Y, Satoh T, Namba T, Sasaki K, Muramoto N, Wada A, Rakugi H, Isaka Y, Hayashi T.: [A case of HIV-associated nephropathy acompanied by nephrotic syndrome and acute worsening of kidney function]. Nippon Jinzo Gakkai Shi (Japanese) 54: 94-98, 2012
15
Isaka Y, Kimura T, Takabatake Y: The protective role of autophagy against aging and acute ischemic injury in kidney proximal tubular cells. Autophagy 7: 1085-1087, 2011
14
Kimura T, Takabatake Y, Takahashi A, Kaimori JY, Matsui I, Namba T, Kitamura H, Niimura F, Matsusaka T, Soga T, Rakugi H, Isaka Y: Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury. J Am Soc Nephrol 22: 902-913, 2011
13
Kimura T, Kitamura H, Inoue K, Kawada N, Matsui I, Nagasawa Y, Obi Y, Shinzawa M, Sakata Y, Hamono T, Rakugi H, Isaka Y: Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease. Clin Exp Nephrol 15(6): 854-860, 2011
12
Kimura T, Inoue K, Omori H, Nagasawa Y, Isaka Y: Haemorrhaghic shock induced by subcutaneous insulin injection. NDT plus 4: 79-80, 2011
11
Miyasato K, Takabatake Y, Kaimori J, Kimura T, Kitamura H, Kawachi H, Li XK, Hunig T, Takahara S, Rakugi H, Isaka Y: CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats. Clin Exp Nephrol 15: 50-57, 2011
10
Nakamori A, Ando Y, Matsuda H, Kimura T, Minami H, Imai E, Yura T: Influence of proteinuria on renal Doppler sonographic measurements in chronic kidney disease and in diabetes mellitus. J Clin Ultrasound 39: 506-511, 2011
9
Kimura T, Obi Y, Yasuda K, Sasaki KI, Takeda Y, Nagai Y, Imai E, Rakugi H, Isaka Y, Hayashi T: Effects of chronic kidney disease and post-angiographic acute kidney injury on long-term prognosis after coronary artery angiography. Nephrol Dial Transplant 26(6): 1838-1846, 2011
8
Kimura T, Iio K, Imai E, Rakugi H, Isaka Y, Hayashi T: Exercise-induced acute kidney injury with reversible posterior leukoencephalopathy syndrome. Clin Exp Nephrol 14: 173-175, 2010
7
Obi Y, Kimura T, Nagasawa Y, Yamamoto R, Yasuda K, Sasaki K, Kitamura H, Imai E, Rakugi H, Isaka Y, Hayashi T: Impact of age and overt proteinuria on outcomes of stage 3 to 5 chronic kidney disease in a referred cohort. Clin J Am Soc Nephrol 5: 1558-1565, 2010
6
Yasuda K, Kimura T, Obi Y, Sasaki K, Hatanaka M, Isaka Y, Rakugi H, Hayashi T: [Plasma B-type natriuretic peptide level predicts the renal outcome in patients with chronic kidney disease]. Nippon Jinzo Gakkai Shi (Japanese) 52: 1007-1014, 2010
5
Kimura T, Yasuda K, Obi Y, Kobayashi K, Kuhara T, Isaka Y, Imai E, Rakugi H, Hayashi T: Quiz page June 2009: worsening kidney function with a history of urolithiasis. Am J Kidney Dis 53: A37-39, 2009
4
Inoue K, Nagasawa Y, Yamamoto R, Omori H, Kimura T, Tomida K, Furumatsu F, Imai E, Isaka Y, Rakugi H: Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug NDT plus 2: 152-154, 2009
3
Iio K, Nagasawa Y, Kimura T, Yamasaki K, Takeda Y, Hamano T, Iwatani H, Sumitsuji S, Nagai Y, Ito T, Imai E, Hayashi T: Assessment of coronary stenosis by a 16-slice MDCT scanner in asymptomatic diabetic patients starting dialysis therapy. Nephron Clin Pract 109: c72-79, 2008
2
Hayashi T, Obi Y, Kimura T, Iio KI, Sumitsuji S, Takeda Y, Nagai Y, Imai E: Cardiac troponin T predicts occult coronary artery stenosis in patients with chronic kidney disease at the start of renal replacement therapy. Nephrol Dial Transplant 23(9): 2936-2942, 2008
1
Kimura T, Iio K, Obi Y, Hayashi T: [Left ventricular hypertrophy in predialysis chronic kidney disease: impact of cardiomuscular stress markers]. Nippon Jinzo Gakkai Shi (Japanese) 49: 1007-1013, 2007
Commentaries
6
Kimura T, personal communication: Unraveling the D-Amino Acid Mystery. the Pathologist 53: 9, 2019
5
Kimura T: Reverse translational research of autophagy and metabolism in kidney disease: Oshima Award Address 2018. Clinical and Experimental Nephrology 23, 733-738, 2019