PUBLICATIONS

*corresponding author

2024

  • Moriyama T., Yoritate M., Kato N., Saika A., Kusuhara W., Ono S., Nagatake T., Koshino H., Kiya N., Moritsuka N., Tanabe R., Hidaka Y., Usui K., Chiba S., Kudo N., Nakahashi R., Igawa K., Matoba H., Tomooka K., Ishikawa E., Takahashi S., Kunisawa J., Yamasaki S., and Hirai G. Linkage-editing pseudo-glycans: A reductive α-fluorovinyl- C-glycosylation strategy to create glycan analogs with altered biological activities. J Am Chem Soc 146(3):2237-2247, 2024 (doi: 10.1021/jacs.3c12581)
  • Yamasaki-Yashiki S., Sakamoto Y., Nishimura K., Saika A., Ito T., Kunisawa J., and Katakura Y. High productivity of immunostimulatory membrane vesicles of Limosilactobacillus antri using glycine. Biosci Microbiota Food Health 43(1):55-63, 2024 (doi: 10.12938/bmfh.2023-029.)
  • Iwasaka C., Nanri H., Nakagata T., Ohno H., Tanisawa K., Konishi K., Murakami H., Hosomi K., Park J., Yamada Y., Ono R., Mizuguchi K,. Kunisawa J., and Miyachi M. Association of skeletal muscle function, quantity, and quality with gut microbiota in Japanese adults: A cross-sectional study. Geriatr Gerontol Int 24(1):55-63, 2024 (doi: 10.1111/ggi.14751.)
  • Sun X., Hosomi K., Shimoyama A., Yoshii K., Saika A., Yamaura H., Nagatake T., Kiyono H., Fukase K., *Kunisawa J., Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue. Int Immunol 36(1):33-43, 2024 (doi: 10.1093/intimm/dxad045.)
  • Yoshimura E., Hamada Y., Hatamoto Y., Nakagata T., Nanri H., Nakayama Y., Hayashi T., Suzuki I., Ando T., Ishikawa-Takata K., Tanaka S., Ono R., Park J., Hosomi K., Mizuguchi K., Kunisawa J., Miyachi M., Effects of energy loads on energy and nutrient absorption rates and gut microbiome in humans: A randomized crossover trial. Obesity (Silver Spring) 32(2):262-272, 2024 (doi: 10.1002/oby.23935)
  • 吉井健、國澤純 ワクチンの将来を切り開く周辺技術の新展開 臨床免疫・アレルギー科（印刷中）
  • 近藤早希、國澤純 個人ごとに適した栄養指導の実現のために～精密栄養学から考える未来の栄養指導～ 日本栄養士会雑誌 2(67):67-72. 2024

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2023

  • Kawai A., Tokunoh N., Kawahara E., Tamiya S., Okamura S., Ono C., Anindita J., Tanaka H., Akita H., Yamasaki S., Kunisawa J., Okamoto T., Matsuura Y., Hirai T., Yoshioka Y., Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses. J Clin Invest 133(23):e166827, 2023 (doi: 10.1172/JCI166827.)
  • Kasahara N., Imi Y., Amano R., Shinohara M., Okada K., Hosokawa Y., Imamori M., Tomimoto C., Kunisawa J., Kishino S., Ogawa J., Ogawa W., Hosooka T., A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells. Sci Rep 13(1):18983, 2023 (doi: 10.1038/s41598-023-46404-5)
  • Kageyama S., Inoue R., Park J., Hosomi K., Yumioka H., Suka T., Teramoto K., Syauki A.Y., Doi M., Sakaue H., Miyake M., Mizuguchi K., Kunisawa J., Irie Y., Changes in fecal gut microbiome of home healthcare patients with disabilities through consumption of malted rice amazake. Physiol Genomics 55(12):647-653,2023 (doi: 10.1152/physiolgenomics.00062.2023)
  • Park J., Bushita H., Nakano A., Hara A., Ueno H.M., Ozato N., Hosomi K., Kawashima H., Chen Y.A., Mohsen A., Ohno H., Konishi K., Tanisawa K., Nanri H., Murakami H., Miyachi M., Kunisawa J., Mizuguchi K., and Araki M., Ramen consumption and gut microbiota diversity in Japanese women: Cross-sectional data from the NEXIS cohort study. Microorganisms 11(8):1892, 2023 (doi: 10.3390/microorganisms11081892.)
  • Kajiyama S., Nagatake T., Ishikawa S., Hosomi K., Shimada Y., Matsui Y., and Kunisawa J., Lentinula edodes mycelia extract regulates the function of antigen-presenting cells to activate immune cells and prevent tumor-induced deterioration of immune function. BMC Complement Med Ther 23(1):281, 2023 (doi: 10.1186/s12906-023-04106-5.)
  • Akazawa N., Nakamura M., Eda N., Murakami H., Nakagata T., Nanri H., Park J., Hosomi K., Mizuguchi K., Kunisawa J., Miyachi M., and Hoshikawa M., Gut microbiota alternation with training periodization and physical fitness in Japanese elite athletes. Front Sports Act Living 5:1219345, 2023 (doi: 10.3389/fspor.2023.1219345.)
  • Sanada T.J., Hosomi K., Park J., Naito A., Sakao S., Tanabe N., Kunisawa J., Tatsumi K., and Suzuki T., Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model. Pulm Circ 13(3):12266, 2023 (doi: 10.1002/pul2.12266.)
  • Maruyama S., Matsuoka T., Hosomi K., Park J., Nishimura M., Murakami H., Konishi K., Miyachi M., Kawashima H., Mizuguchi K., Kobayashi T., Ooka T., Yamagata Z., and Kunisawa J., Characteristic Gut Bacteria in High Barley Consuming Japanese Individuals without Hypertension. Microorganisms 11(5):1246, 2023 (doi: 10.3390/microorganisms11051246.)
  • Tada R., Yamazakia H., Nagai Y., Takeda Y., Ohshima A., Kunisawa J., and Negishi Y., Intranasal administration of sodium nitroprusside augments antigen-specific mucosal and systemic antibody production in mice. Int Immunopharmacol 119:110262, 2023 (doi: 10.1016/j.intimp.2023.110262)
  • Ishida K., Nagatake T., Saika A., Kawai S., Node E., Hosomi K., and Kunisawa J. Induction of unique macrophage subset by simultaneous stimulation with LPS and IL-4. Front Immunol 14:1111729, 2023 (doi: 10.3389/fimmu.2023.1111729)
  • Nakamura Y., Fuse Y., Komiyama S., Nagatake T., Kunisawa J., and Hase K. Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells. Sci Rep 13(1):5398, 2023 (doi: 10.1038/s41598-023-32552-1.)
  • Honda T., Kabashima K., and Kunisawa J., Exploring the roles of prostanoids, leukotriens, and dietary fatty acids in cutaneous inflammatory diseases: Insights from pharmacological and genetic approaches. Immunol Rev 17(1):95-112, 2023 (doi: 10.1111/imr.13193.)
  • Saika A., Tiwari P., Nagatake T., Node E., Hosomi K., Honda T., Kabashima K., and *Kunisawa J., Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha. Front Mol Biosci 10:1097955, 2023 (doi: 10.3389/fmolb.2023.1097955.)
  • *Kunisawa J., Biochemical detection system for intermediates of endogenous antigen and elucidation of the role of molecular chaperones. Cell Immunol 385:104685, 2023 (doi: 10.1016/j.cellimm.2023.104685.)
  • Sun X., Hosomi K., Shimoyama A, Yoshii K., Lan H., Wang Y., Yamaura H., Nagatake T., Ishii K.J., Akira S., Kiyono H., Fukase K., *Kunisawa J., TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells. Int Immunopharmacol 117:109852, 2023 (doi: 10.1016/j.intimp.2023.109852.)
  • Hosomi K., Shimoyama A., Hinenoya A., Hatanaka N., Noguchi T., Ebina H., Tojima Y., Furuta M., Kondoh M., Kiyono H., Yamasaki S., Fukase K., *Kunisawa J., Endotoxin-free Stx2B-C-CPE vaccine and its optimized adjuvant regimen for preventing food poisoning. Front Biosci (Landmark Ed 28(1):15, 2023 (doi: 10.31083/j.fbl2801015.)
  • 眞田喬行、國澤純 新時代のオーダーメイド型栄養学　精密栄養学 臨床栄養 143(7), 900-904, 2023
  • 吉井健、國澤純 腸管粘膜のM細胞と粘膜ワクチン アロス エルゴン 3(2), 1135-1140, 2023
  • 堀田将志、國澤純 食事性脂質からのアレルギー制御 皮膚アレルギーフロンティア 21(2), 17-21, 2023
  • 堀田将志、國澤純 腸内細菌の代謝産物とアレルギー アロス エルゴン 3(1), 1007-1011, 2023
  • 細見晃司、國澤純 食と腸内細菌が織りなす腸内代謝環境の構築と健康への影響 生化学 95(4):450-456, 2023
  • 吉岡拓哉、國澤純 免疫制御ならびに腸内環境構築におけるビタミンB1の役割 FOOD STYLE 8:61-64, 2023
  • 重城喬行、國澤純 「精密栄養学」概論：われわれは何を食べたらよいのか？ 実験医学増刊 健康と疾患を制御する精密栄養学 41(10):8-14, 2023
  • 國澤純 生体防御システムにおけるエネルギー代謝の影響 家畜感染症学会誌 12(2):49-52, 2023
  • 細見晃司、國澤純 腸内細菌叢のリモデリングと肥満・糖尿病 臨床免疫・アレルギー科 79(5): 571-575, 2023
  • 粕谷裕司、國澤純 ＜夢対談＞薬剤学で切り拓く創薬モダリティの未来（2）ワクチン 薬剤学 83(1): 14-18 (2023)

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2022

  • *Kunisawa J., Future prospects for food research in the post-microbiome era. J Nutr Sci Vitaminol (Tokyo) 68: S23-S25, 2022 (doi: 10.3177/jnsv.68.S23.)
  • Sawane K., Nagatake T., Hosomi K., *Kunisawa J., Anti-allergic property of dietary phytoestrogen secoisolariciresinol diglucoside through microbial and β-glucuronidase-mediated metabolism. J Nutr Biochem 112:109219, 2023 (doi: 10.1016/j.jnutbio.2022.109219)
  • Sawane K., Hosomi K., Park J., Ookoshi K., Nanri H., Nakagata T., Chen Y.A., Mohsen A., Kawashima H., Mizuguchi K., Miyachi M., *Kunisawa J., Identification of human gut microbiome associated with enterolignan production. Microorganisms 10(11):2169, 2022 (doi: 10.3390/microorganisms10112169)
  • Hosomi K., Saito M., Park J., Murakami H., Shibata N., Ando M., Nagatake T., Konishi K., Ohno H., Tanisawa K., Mohsen A., Chen Y.A., Kawashima H., Natsume-Kitatani Y., Oka Y., Shimizu H., Furuta M., Tojima Y., Sawane K., Saika A., Kondo S., Yonejima Y., Takeyama H., Matsutani A., Mizuguchi K., Miyachi M., *Kunisawa J., Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota. Nat Commun 13(1):4477, 2022 (doi: 10.1038/s41467-022-32015-7)
  • Liu Z., Hosomi K., *Kunisawa J., Utilization of gut environment-mediated control system of host immunity in the development of vaccine adjuvants. Vaccine 40(36):5399-5403, 2022 (doi: 10.1016/j.vaccine.2022.07.031.)
  • Tada R., Honjo E., Muto S., Takayama N., Kiyono H., Kunisawa J., Negishi Y., Role of interleukin-6 in the antigen-specific mucosal immunoglobulin A responses induced by CpG oligodeoxynucleotide-loaded cationic liposomes. Membranes (Basel) 12(6):635, 2022 (doi: 10.3390/membranes12060635).
  • Park J., Hosomi K., Kawashima H., Chen Y.A., Mohsen A., Ohno H., Konishi K., Tanisawa K., Kifushi M., Kogawa M., Takeyama H., Murakami H., Kubota T., Miyachi M., *Kunisawa J., Mizuguchi K., Dietary vitamin B1 intake influences gut microbial community and the consequent production of short-chain fatty acids. Nutrients 14(10):2078, 2022 (doi: 10.3390/nu14102078.)
  • Ikubo Y., Sanada T.J., Hosomi K., Park J., Naito A., Shoji H., Misawa T., Suda R., Sekine A., Sugiura T., Shigeta A., Nanri H., Sakao S., Tanabe N., Mizuguchi K., Kunisawa J., Suzuki T., Tatsumi K. Altered gut microbiota and its association with inflammation in patients with chronic thromboembolic pulmonary hypertension: a single-center observational study in Japan. BMC Pulm Med 22(1):138, 2022 (doi: 10.1186/s12890-022-01932-0.)
  • Maruyama S., Matsuoka T., Hosomi K., Park J., Nishimura M., Murakami H., Konishi K., Miyachi M., Kawashima H., Mizuguchi K., Kobayashi T., Ooka T., Yamagata Z., Kunisawa J., Classification of the occurrence of dyslipidemia based on gut bacteria related to barley intake. Front Nutrition 9:84, 2022 (doi: 10.3389/fnut.2022.812469. eCollection 2022.)
  • Tourlousse D.M., Narita K., Miura T., Ohashi A., Matsuda M., Ohyama Y., Shimamura M., Furukawa M., Kasahara K., Kameyama K., Saito S., Goto M., Shimizu R., Mishima R., Nakayama J., Hosomi K., Kunisawa J., Terauchi J., Sekiguchi Y., Kawasaki H., Characterization and Demonstration of Mock Communities as Control Reagents for Accurate Human Microbiome Community Measurements. Microbiol Spectr 10(2):e0191521, 2022 (doi: 10.1128/spectrum.01915-21.)
  • Matsuoka T., Hosomi K., Park J., Goto Y., Nishimura M., Nakashima S., Murakami H., Konishi K., Miyachi M., Kawashima H., Mizuguchi K., Kobayashi T., Yokomichi H., *Kunisawa J., and Yamagata Z., Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study. BMC Nutrition 8(1):23, 2022 (doi: 10.1186/s40795-022-00500-3.)
  • Nagatake T., Shibata Y., Morimoto S., Node E., Sawane K., Hirata S.I., Adachi J., Abe Y., Isoyama J., Saika A., Hosomi K., Tomonaga T., and *Kunisawa J., 12-hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice. Sci Rep 11(1):10426, 2021 (doi: 10.1038/s41598-021-89707-1.)
  • Otoshi T., Nagano T., Park J., Hosomi K., Yamashita T., Tachihara M., Tabata T., Sekiya R., Tanaka Y., Kobayashi K., Mizuguchi K., Itoh T., Maniwa Y., Kunisawa J., Nishimura Y., The Gut Microbiome as a Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma. Anticancer Res 42(3):1589-1598, 2022 (doi: 10.21873/anticanres.15633.)
  • Nagatake T., Kishino S., Urano E., Murakami H., Kitamura N., Konishi K., Ohno H., Tiwari P., Morimoto S., Node E., Adachi J., Abe Y., Isoyama J., Sawane K., Honda T., Inoue A., Uwamizu A., Matsuzaka T., Miyamoto Y., Hirata S.I., Saika A., Shibata Y., Hosomi K., Matsunaga A., Shimano H., Arita M., Aoki J., Oka M., Matsutani A., Tomonaga T., Kabashima K., Miyachi M., Yasutomi Y., Ogawa J., and *Kunisawa J., Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques. Mucosal Immunol 15(2):289-300, 2022 (doi: 10.1038/s41385-021-00477-5.)
  • Miki Y., Taketomi Y., Kidoguchi Y., Yamamoto K., Muramatsu K., Nishito Y., Park J., Hosomi K., Mizuguchi K., Kunisawa J., Soga T., Boilard E., B Gowda S.G., Ikeda K., Arita M., and Murakami M.., Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota. JCI Insight 7(2): e152611, 2022
  • Kamioka M., Goto Y., Nakamura K., Yokoi Y., Sugimoto R., Ohira S., Kurashima Y., Umemoto S., Sato S., Kunisawa J., Takahashi Y., Domino S.E., Renauld J.C., Nakae S., Iwakura Y., Ernst P.B., Ayabe T., Kiyono H., Intestinal commensal microbiota and cytokines regulate Fut2 + Paneth cells for gut defense. Proc Natl Acad Sci USA 119(3):e2115230119, 2022 (doi: 10.1073/pnas.2115230119.)
  • Hosomi K., Saito M., Park J., Murakami H., Shibata N., Ando M., Nagatake T., Konishi K., Ohno H., Tanisawa K., Mohsen A., Chen Y.A., Kawashima H., Natsume-Kitatani Y., Oka Y., Shimizu H., Furuta M., Tojima Y., Sawane K., Saika A., Kondo S., Yonejima Y., Takeyama H., Matsutani A., Mizuguchi K., Miyachi M., *Kunisawa J., Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota. Nat Commun 13(1):4477, 2022 (doi: 10.1038/s41467-022-32015-7)
  • Sawane K, Nagatake T, Hosomi K, Kunisawa J., Anti-allergic property of dietary phytoestrogen secoisolariciresinol diglucoside through microbial and β-glucuronidase-mediated metabolism. J Nutr Biochem 109219, 2022
  • Swane K, Hosomi K, Park J, Ookoshi K, Nanri H, Nakagata T, Chen YA, Mohsen A, Kawashima H, Mizuguchi K, Miyachi M, Kunisawa J. Identification of Human Gut Microbiome Associated with Enterolignan Production. Microorganisms 10(11):2169, 2022
  • Liu Z, Hosomi K, Kunisawa J. Utilization of gut environment-mediated control system of host immunity in the development of vaccine adjuvants. Vaccine 0264-410X(22)00918-5, 2022
  • Park J, Hosomi K, Kawashima H, Chen YA, Mohsen A, Ohno H, Konishi K, Tanisawa K, Kifushi M, Kogawa M, Takeyama H, Murakami H, Kubota T, Miyachi M, Kunisawa J, Mizuguchi K. Dietary Vitamin B1 Intake Influences Gut Microbial Community and the Consequent Production of Short-Chain Fatty Acids. Nutrients 14(10):2078, 2022
  • Ikubo Y, Sanada TJ, Hosomi K, Park J, Naito A, Shoji H, Misawa T, Suda R, Sekine A, Sugiura T, Shigeta A, Nanri H, Sakao S, Tanabe N, Mizuguchi K, Kunisawa J, Suzuki T, Tatsumi K. Altered gut microbiota and its association with inflammation in patients with chronic thromboembolic pulmonary hypertension: a single-center observational study in Japan. BMC Pulm. Med. 22(1):138, 2022
  • Maruyama S, Matsuoka T, Hosomi K, Park J, Nishimura M, Murakami H, Konishi K, Miyachi M, Kawashima H, Mizuguchi K, Kobayashi T, Ooka T, Yamagata Z, Kunisawa J. Classification of the Occurrence of Dyslipidemia Based on Gut Bacteria Related to Barley Intake. Front. Nutrition 9:84, 2022 (doi: 10.3389/fnut.2022.812469. eCollection 2022.)
  • Tourlousse DM, Narita K, Miura T, Ohashi A, Matsuda M, Ohyama Y, Shimamura M, Furukawa M, Kasahara K, Kameyama K, Saito S, Goto M, Shimizu R, Mishima R, Nakayama J, Hosomi K, Kunisawa J, Terauchi J, Sekiguchi Y, Kawasaki H. Characterization and Demonstration of Mock Communities as Control Reagents for Accurate Human Microbiome Community Measurements. Microbiol. Spectr. 10(2):e0191521, 2022 (doi: 10.1128/spectrum.01915-21.)
  • Matsuoka T, Hosomi K, Park J, Goto Y, Nishimura M, Maruyama S, Murakami H, Konishi K, Miyachi M, Kawashima H, Mizuguchi K, Kobayashi T, Yokomichi H, Kunisawa J, Yamagata Z. Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study. BMC Nutr. 8(1):23, 2022
  • Nagatake T., Shibata Y., Morimoto S., Node E., Sawane K., Hirata S.I., Adachi J., Abe Y., Isoyama J., Saika A., Hosomi K., Tomonaga T., and *Kunisawa J., 12-hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice. Sci Rep 11(1):10426, 2021 (doi: 10.1038/s41598-021-89707-1.)
  • Otoshi T, Nagano T, Park J, Hosomi K, Yamashita T, Tachihara M, Tabata T, Sekiya R, Tanaka Y, Kobayashi K, Mizuguchi K, Itoh T, Maniwa Y, Kunisawa J, Nishimura Y. The Gut Microbiome as a Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma. Anticancer Res. 42(3):1589-1598, 2022
  • Miki Y, Taketomi Y, Kidoguchi Y, Yamamoto K, Muramatsu K, Nishito Y, Park J, Hosomi K, Mizuguchi K, Kunisawa J, Soga T, Boilard E, B Gowda SG, Ikeda K, Arita M, Murakami M. Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota. JCI Insight 7(2):e152611, 2022
  • 1agatake T, Kishino S, Urano E, Murakami H, Kitamura N, Konishi K, Ohno H, Tiwari P, Morimoto S, Node E, Adachi J, Abe Y, Isoyama J, Sawane K, Honda T, Inoue A, Uwamizu A, Matsuzaka T, Miyamoto Y, Hirata SI, Saika A, Shibata Y, Hosomi K, Matsunaga A, Shimano H, Arita M, Aoki J, Oka M, Matsutani A, Tomonaga T, Kabashima K, Miyachi M, Yasutomi Y, Ogawa J, Kunisawa J. Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques. Mucosal Immunol. 15(2):289-300, 2022
  • Iwasaki M, Kanehara R, Yamaji T, Katagiri R, Mutoh M, Tsunematsu Y, Sato M, Watanabe K, Hosomi K, Kakugawa Y, Ikematsu H, Hotta K, Kunisawa J, Wakabayashi K, Matsuda T. Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan. Cancer Sci. 113(1):277-286, 2022
  • Kondo S., Karasawa T., Fukazawa A., Koike A., Tsutsui M., Terada S. Effects of a Very High-Carbohydrate Diet and Endurance Exercise Training on Pancreatic Amylase Activity and Intestinal Glucose Transporter Content in Rats. Journal of nutritional science and vitaminology 68(2):97–103, 2022 (DOI: 10.3177/jnsv.68.97)
  • 細見晃司、國澤純 DDSに立脚した粘膜ワクチンの開発 Drug Delivery System 37(5): 284-292, 2022
  • 河合総一郎、國澤純 栄養学の視点で医学、健康栄養政策まで世界の最新研究を紹介 栄養学レビュー 80(4): 3-12,2022
  • 雑賀あずさ、國澤純 腸内環境から考えるアレルギー制御 アレルギーの臨床42(12): 24-27, 2022
  • 細見晃司、國澤純　DDSに立脚した粘膜ワクチンの開発　Drug Delivery System 37(5): 284-292, 2022
  • 吉井健、細見晃司、國澤純　腸内環境を介した免疫制御とワクチン研究への展開　Precision Medicine, 2022
  • 細見晃司、國澤純　ポストバイオティクス研究から考える健康科学の将来と個別化栄養　Food Style 21 26(6), 2022
  • 河合総一郎、國澤純 栄養学の視点で医学、健康栄養政策まで世界の最新研究を紹介 栄養学レビュー80(4): 3-12,2022
  • 長竹貴広、國澤純. 免疫バランス制御におけるオメガ3脂肪酸代謝物の働きとメカニズム解明 食品と開発 57(2): 18-20, 2022

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2021

  • Tomizawa R., Park J., Hosomi K., Matsumoto N., Kawashima H., Mizuguchi K., Kunisawa J., and Honda C., Relationship between human gut microbiota and nutrition Intake in hypertensive discordant monozygotic twins. J Hypertens (Los Angel) 10(8):297, 2021
  • Kageyama S., Inoue R., Hosomi K., Park J., Yumioka H., Suka T., Kurohashi Y., Teramoto K., Syauki A.Y., Doi M., Sakaue H., Mizuguchi K., Kunisawa J., Irie Y., Effects of Malted Rice Amazake on Constipation Symptoms and Gut Microbiota in Children and Adults with Severe Motor and Intellectual Disabilities: A Pilot Study. Nutrients 13(12):4466, 2021 (doi: 10.3390/nu13124466.)
  • Ueta M., Hosomi K., Park J., Mizuguchi K., Sotozono C., Kinoshita S., *Kunisawa J., Categorization of the ocular microbiome in Japanese Stevens-Johnson syndrome patients with severe ocular complications. Front Cell Infect Microbiol 11:741654, 2021 (doi: 10.3389/fcimb.2021.741654.)
  • Iwasaki M., Kanehara R., Yamaji T., Katagiri R., Mutoh M., Tsunematsu Y., Sato M., Watanabe K., Hosomi K., Kakugawa Y., Ikematsu H., Hotta K., Kunisawa J., Wakabayashi K., Matsuda T., Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan. Cancer Sci 113(1):277-286, 2021 (doi: 10.1111/cas.15196.)
  • Liu Z., Hosomi K., Shimoyama A., Yoshii K., Sun X., Lan H., Wang Y., Yamaura H., Kenneth D., Saika A., Nagatake T., Kiyono H., Fukase K., and *Kunisawa J., Chemically synthesized Alcaligenes lipid A as an adjuvant to augment immune responses to Haemophilus Influenzae type B conjugate vaccine. Front Pharmacol 12:763657, 2021 (doi: 10.3389/fphar.2021.763657.)
  • Tada R., Hidaka A., Tanazawa Y., Ohmi A., Muto S., Ogasawara M., Saito M., Ohshima A., Iwase N., Honjo E., Kiyono H., Kunisawa J., and Negishi Y., Role of interleukin-6 in antigen-specific mucosal immunoglobulin A induction by cationic liposomes. Int Immunopharmacol 101:108280, 2021 (doi: 10.1016/j.intimp.2021.108280.)
  • Tsunematsu Y., Hosomi K., Kunisawa J., Sato M., Shibuya N., Saito E., Murakami H, Yoshikawa Y, Iwashita Y, Miyoshi N, Mutoh M, Ishikawa H, Sugimura H, Miyachi M, Wakabayashi K, Watanabe K., Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria. BMC Microbiol 24(1):235, 2021 (doi: 10.1186/s12866-021-02292-1.)
  • Wang Y., Hosomi K., Shimoyama A., Yoshii K., Nagatake T., Fujimoto Y., Kiyono H., Fukase K., and *Kunisawa J., Lipopolysaccharide derived from the lymphoid-resident commensal bacteria Alcaligenes faecalis functions as an effective nasal adjuvant to augment IgA antibody and Th17 cell responses. Front Immunol 12:699349, 2021 (doi: 10.3389/fimmu.2021.699349)
  • Matsuzaki C., Nakashima Y., Endoc I., Tomabechi Y., Higashimura Y., Itonorie S., Hosomi K., Kunisawa J., Yamamoto K., Hisa K., Enzymatically synthesized exopolysaccharide of a probiotic strain Leuconostoc mesenteroides NTM048 shows adjuvant activity to promote IgA antibody responses. Gut Microbes 13(1):194909, 2021 (doi: 10.1080/19490976.2021.1949097)
  • Watanabe D., Murakami M., Ohno H., Tanisawa K., Konishi K., Todoroki-Mori K., Tsunematsu Y., Sato M., Ogata Y., Miyoshi N., Kubota N., Kunisawa J., Wakabayashi K., Kubota T., Watanabe K., and Miyachi M., Stool pattern is associated with not only the prevalence of tumorigenic bacteria isolated from fecal matter but also plasma and fecal fatty acids in healthy Japanese adults. BMC Microbiol 21(1):196, 2021 (doi: 10.1186/s12866-021-02255-6)
  • Park J., Kato K., Murakami H., Hosomi K., Tanisawa K., Nakagata T., Ohno H., Konishi K., Kawashima H., Chen Y.A., Mohsen A., Xiao J.Z., Odamaki T., *Kunisawa J., Mizuguchi K., and Miyachi M., Comprehensive analysis of gut microbiota of a healthy population and covariates affecting microbial variation in two large Japanese cohorts. BMC Microbiol 21(1):151, 2021 (doi: 10.1186/s12866-021-02215-0.)
  • Nagatake T., Shibata Y., Morimoto S., Node E., Sawane K., Hirata S.I., Adachi J., Abe Y., Isoyama J., Saika A., Hosomi K., Tomonaga T., and *Kunisawa J., 12-hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice. Sci Rep 11(1):10426, 2021 (doi: 10.1038/s41598-021-89707-1.)
  • Tada R., Suzuki H., Ogasawara M., Yamanaka D., Adachi Y., Kunisawa J., Negishi Y. Polymeric caffeic acid acts as a nasal vaccine formulation against Streptococcus pneumoniae infections in mice. Pharmaceutics 13(4): 585, 2021 (doi: 10.3390/pharmaceutics13040585.)
  • Oka A., Kidoguchi M., Kariya S., Fujiwara T., Yuta A., Miyashita H., Higaki T, Ogawa Y., Kanai K., Makihara S.I., Haruna T., Kunisawa J., Adachi N., Koyama K., Ii R., Noguchi E., Fujieda S., Nishizaki K., Okano M. Role of salivary microbiome in IL-10 production and efficacy of sublingual immunotherapy. Allergy 76(8):2617-2620, 2021 (doi: 10.1111/all.14858.)
  • Matsumoto N., Park J., Tomizawa R., Kawashima H., Hosomi K., Mizuguchi K., Honda C., Ozaki R., Iwatani Y., Watanabe M., Kunisawa J. Relationship between nutrient intake and human gut microbiota in monozygotic twins. Medicina (Kaunas) 57(3): 275, 2021 (doi: 10.3390/medicina57030275.)
  • Shimoyama A., Di Lorenzo F., Yamaura H., Mizote K., Palmigiano A., Pither M.D., Speciale I., Uto T., Masui S., Sturiale L., Garozzo D., Hosomi K., Shibata N., Kabayama K., Fujimoto Y., Silipo A., Kunisawa J., Kiyono H., Molinaro A., Fukase K., Lipopolysaccharide from gut-associated lymphoid tissue-resident Alcaligenes faecalis: complete structure determination and chemical synthesis of its lipid As. Angew Chem Int Ed Engl 60(18): 10023-10031, 2021 (doi: 10.1002/anie.202012374)
  • Saika A., Nagatake T., Hirata S.I., Sawane K., Adachi J., Abe Y., Isoyama J., Morimoto S., Node E., Tiwari P., Hosomi K., Matsunaga A., Honda T., Tomonaga T., Arita M., Kabashima K., and *Kunisawa J., ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α. FASEB J 35(4):e21354, 2021
  • Tada R., Ogasawara M., Yamanaka D., Sakurai Y., Negishi Y., Kiyono H., Ohno N., Kunisawa J., and Aramaki Y., Enzymatically polymerised polyphenols prepared from various precursors potentiate antigen-specific immune responses in both mucosal and systemic compartments in mice. PLoS One 16(2): e0246422, 2021
  • Takasato Y., Kurashima Y., Kiuchi M., Hirahara K., Murasaki S., Arai F., Izawa K., Kaitani A., Shimada K., Saito Y., Toyoshima S., Nakamura M., Fujisawa K., Okayama Y., Kunisawa J., Kubo M., Takemura N., Uematsu S., Akira S., Kitaura J., Takahashi T., Nakayama T., Kiyono H., Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol 14(3):640-651, 2021 (doi: 10.1038/s41385-020-00358-3)
  • Tabata T., Yamashita T., Hosomi K, Park J., Hayashi T., Yoshida N., Saito Y., Fukuzawa K., Konishi K., Murakami H., Kawashima H., Mizuguchi K., Miyachi M., Kunisawa J., Hirata K.I. Gut microbial composition in patients with atrial fibrillation: Effects of diet and drugs. Heart and Vessels 36(1):105-114, 2021 (doi: 10.1007/s00380-020-01669-y)
  • 雑賀あずさ、國澤純 腸内環境を介した脂質メディエーターの産生と炎症の制御 Medical Science Digest 48(1): 24-27, 2021
  • 國澤純 腸内細菌との相互作用により作り出される食の免疫制御機能と社会実装への試み　ファンクショナルフード学会誌 (17): 148-155, 2021
  • 細見晃司、國澤純 粘膜面における獲得免疫と感染防御 医学のあゆみ 279(10):937-942, 2021
  • 長竹貴広、國澤純 皮膚に及ぼす食の免疫学的影響の理解と応用 日本香粧品学会誌 45(4):348-352, 2021
  • 近藤早希、國澤純 腸管レジデントB細胞 炎症と免疫 30(1): 106-109, 2022
  • 石田渓、長竹貴広、國澤純 腸内環境を介した免疫制御とアレルギー・炎症との関わり リンパ学44(2): 77-81, 2021
  • 國澤純 アカデミア創薬におけるイノベーションとレギュレーションの課題　Biophilia (36): 18-22, 2021
  • 雑賀あずさ、國澤純 食と腸内細菌が作り出す脂質環境の理解と疾患予防戦略への展開 YAKUGAKU ZASSHI141(5): 681-688, 2021
  • 國澤純　粘膜における免疫恒常性、標準免疫学第4版（監修、宮坂昌之; 編集、小安重夫、椛島健治）、医学書院、p217-225, 2021
  • 長竹貴広、國澤純 加齢による免疫フレイル・炎症・脂質代謝 BIOINDUSTRY 38(1): 41-51, 2021
  • 國澤純　消化管の免疫系、食品免疫学事典（編集、日本食品免疫学会）、朝倉書店、74-75, 2021
  • 國澤純　食事と腸内細菌、食品免疫学事典（編集、日本食品免疫学会）、朝倉書店、234-235, 2021
  • 國澤純　ω-3系、ω-6系脂肪酸、食品免疫学事典（編集、日本食品免疫学会）、朝倉書店、318-319, 2021
  • 長竹貴広、國澤純　加齢による免疫フレイル・炎症・脂質代謝、フレイル予防と予防医学 －諸研究分野の視点から「フレイル予防」及び「予防医学」を考える－（監修、矢澤一良）、シーエムシー出版、p45-55, 2021
  • 石田渓、長竹貴広、國澤純　ω3脂肪酸代謝物に見出された新たな抗炎症・抗アレルギー作用、オメガ3脂肪酸の技術と市場（監修、小川順）、シーエムシー出版、p52-61, 2021
  • 雑賀あずさ、國澤純　オメガ3脂肪酸代謝物によるアレルギー性皮膚炎抑制メカニズムの解明と予防・治療法の開発展望、進化する皮膚科学　機能研究・臨床・評価・製品開発の最前線、エヌ・ティー・エス、p255-262, 2021
  • 國澤純　粘膜における免疫恒常性、標準免疫学第4版（監修、宮坂昌之; 編集、小安重夫、椛島健治）、医学書院、p217-225, 2021

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2020

  • Chen Y.A., Park J., Natsume-Kitatani Y., Kawashima H., Mohsen A., Hosomi K., Tanisawa K., Ohno H., Konishi K., Murakami H., Miyachi M., Kunisawa J., Mizuguchi K., MANTA, an integrative database and analysis platform that relates microbiome and phenotypic data. PLoS One 15(12):e0243609, 2020 (doi: 10.1371/journal.pone.0243609)
  • Hosomi K., Shibata N., Shimoyama A., Uto T., Nagatake T., Tojima Y., Nishino T., Takeyama H., Fukase K., Kiyono H., *Kunisawa J., Lymphoid tissue-resident Alcaligenes establish an intracellular symbiotic environment by creating a unique energy shift in dendritic cells. Front Microbiol 11:561005, 2020 (doi: 10.3389/fmicb.2020.561005)
  • Nagatake T., Yan-Chun Z., Ito T., Itoh M., Kometani K., Furuse M., Saika A., Node E., Kunisawa J., Minato N., Hamazaki Y., Selective expression of claudin-5 in thymic endothelial cells regulates the blood-thymus barrier and T-cell export. Int Immunol 33(3):171-182, 2020 (doi: 10.1093/intimm/dxaa069)
  • Hosomi K., *Kunisawa J., Impact of the intestinal environment on the immune responses to vaccination. Vaccine 38(44):6959-6965, 2020 (doi: 10.1016/j.vaccine.2020.08.079.)
  • Sanada T.J., Hosomi K., Shoji H., Park J., Naito A., Ikubo Y., Yanagisawa A., Kobayashi T., Miwa H., Suda R., Sakao S., Mizuguchi K., Kunisawa J., Tanabe N., Tatsumi K., Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model. Pulm Circ 10(3):2045894020929147, 2020 (doi: 10.1177/2045894020929147)
  • Hirata S.I., Sawane K., Adachi J., Isoyama .J, Sugiura Y., Matsunaga A., Hosomi K., Tomonaga T., Suematsu M., Nagatake T., *Kunisawa J., Vitamin B1 supports the differentiation of T cells through TGF-β superfamily production in thymic stromal cells. iScience 23(9):101426, 2020 (doi: 10.1016/j.isci.2020.101426)
  • Yoshii K., Hosomi K., Shimoyama A., Wang Y., Yamaura H., Nagatake T., Suzuki H., Lan H., Kiyono H., Fukase K., *Kunisawa J., Chemically synthesized Alcaligenes lipid A shows a potent and safe nasal vaccine adjuvant activity for the induction of Streptococcus pneumoniae-specific IgA and Th17 mediated protective immunity. Microorganisms 8(8):1102, 2020 (doi: 10.3390/microorganisms8081102)
  • Wang Y., HosomiK., Shimoyama A., Yoshii K., Yamaura H., Nagatake T., Nishino T., Kiyono H., Fukase K., and *Kunisawa J., Adjuvant activity of synthetic lipid A of Alcaligenes, a gut-associated lymphoid tissue-resident commensal bacterium, to augment antigen-specific IgG and Th17 responses in systemic vaccine. Vaccines (Basel) 8(3):E395, 2020 (doi: 10.3390/vaccines8030395)
  • Lan H., Suzuki H., Nagatake T., Hosomia K., Ikegami K., Setou M., and *Kunisawa J. Impaired mucociliary motility enhances antigen-specific nasal IgA immune responses to cholera toxin-based nasal vaccine. Int Immunol 32(8):559-568, 2020 (doi: 10.1093/intimm/dxaa029)
  • Hosomi K, *Kunisawa J, Diversity of energy metabolism in immune responses regulated by microorganisms and dietary nutrition. Int Immunol 32(7):447-454, 2020 (doi: 10.1093/intimm/dxaa020)
  • Sato E., Hosomi K., Sekimoto A., Mishima E., Oe Y., Saigusa D., Ito S., Abe T., Sato H., Kunisawa J., Niwa T., Takahashi N. Effects of the Oral Adsorbent AST-120 on Fecal P-Cresol and Indole Levels and on the Gut Microbiota Composition. Biochem Biophys Res Commun 525(3):773-779, 2020 (doi: 10.1016/j.bbrc.2020.02.141)
  • Nakamura Y., Mimuro H., Kunisawa J., Furusawa Y., Takahashi D., Fujimura Y., Kaisho T., Kiyono H., Hase K. Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity. Mucosal Immunol 13(4):679-690, 2020 (doi: 10.1038/s41385-020-0263-0)
  • Hirata S.I., Nagatake T., Sawane K., Hosomi K., Honda T., Ono S., Shibuya N., Saito E., Adachi J., Abe Y., Isoyama J., Suzuki H., Matsunaga A., Tomonaga T., Kiyono H., Kabashima K., Arita M., *Kunisawa J. Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. Allergy 75(8):1935-1951, 2020 (doi: 10.1111/all.14217)
  • Takahashi I., Hosomi K., Nagatake T., Tobou H., Yamamoto D., Hayashi I., Kurashima Y., Sato S., Shibata N., Goto Y., Maruyama F., Nakagawa I., Kuwae A., Abe A., *Kunisawa J., and Kiyono H., Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia. Int Immunol 32(2):133-141, 2020
  • 細見晃司、國澤純　腸内免疫学から考える新しいワクチン学 小児科 61(11): 1545-1552, 2020
  • 長竹貴広、國澤純 アレルギー性皮膚炎を改善するω3脂肪酸代謝物の作用機構　フレグランスジャーナル 11: 45-50, 2020
  • 長竹貴広、國澤純 オメガ3, オメガ6必須脂肪酸代謝物による免疫制御 生物工学会誌 98(10): 544-548, 2020
  • 雑賀あずさ、國澤純　＜研究室紹介＞食事と腸内細菌を介した免疫制御研究 腸内細菌学雑誌 34(4): 217-220, 2020
  • 石田渓、長竹貴広、國澤純　ω3脂肪酸代謝物に見出された新たな抗炎症・抗アレルギー作用 月刊BIO INDUSTRY 37(10): 53-62, 2020
  • 雑賀あずさ、國澤純　食事性脂質を起点としたアレルギー疾患と粘膜ワクチン応答の制御 アレルギー 60(5): 324-328, 2020
  • 平田宗一郎、國澤純　アマニ油による健康効果と腸内細菌の代謝の関与 食と医療 13: 64-69, 2020
  • 細見晃司、國澤純　腸内細菌叢研究とデータの取得・解析 コスメティックステージ 14(4): 40-48, 2020
  • 長竹貴広、國澤純 免疫・アレルギー・炎症を制御する必須脂肪酸代謝物の新機能 脂質・脂肪酸関連物質の使いこなし方　素材開発・機能創生・応用技術（監修：石井淑夫）（テクノシステム）239-246, 2020
  • 河合総一郎、細見晃司、國澤純 腸内細菌叢解析の外部委託時の注意点と活用の考え方 腸内細菌叢の基礎知識と研究開発における留意点（情報機構）85-96, 2020
  • 平田宗一郎、國澤純　腸管上皮細胞による多彩なバリア（M細胞、パネート細胞は除く） 消化器病学サイエンス 4(1): 59-63, 2020
  • 長竹貴広、國澤純　必須脂肪酸代謝物による免疫制御の実体解明 FOOD Style 21 24(3): 31-34, 2020
  • 雑賀あずさ、國澤純　食事性脂質の摂取と腸内細菌叢との相互作用を介したアレルギー疾患制御の可能性 ILSI Japan 141: 12-21, 2020
  • 長竹貴広、國澤純　オメガ3、オメガ6、オメガ9脂肪酸の代謝による新たな免疫・アレルギー・炎症の制御機構～食用油を使い分けてより健康に～ 化学と生物 58(2): 97-103, 2020
  • 松永安由、國澤純　食と腸内細菌叢から考える健康社会の近未来 食文化研究 15: 62-66, 2020
  • 長竹貴広、國澤純　プロバイオティクス、プレバイオティクス、シンバイオティクスとは 糖尿病ケア 17(1): 16-18, 2020
  • 細見晃司、國澤純　善玉菌・悪玉菌とは 糖尿病ケア 17(1): 14-15, 2020
  • 長竹貴広、國澤純 免疫・アレルギー・炎症を制御する必須脂肪酸代謝物の新機能 脂質・脂肪酸関連物質の使いこなし方　素材開発・機能創生・応用技術（監修：石井淑夫）（テクノシステム）239-246, 2020
  • 河合総一郎、細見晃司、國澤純 腸内細菌叢解析の外部委託時の注意点と活用の考え方 腸内細菌叢の基礎知識と研究開発における留意点（情報機構）85-96, 2020

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2019

  • Saika A., Nagatake T., Kishino S., Park S.B., Honda T., Matsumoto N., Shimojou M., Morimoto S., Tiwari P., Node E., Hirata S.I., Hosomi K., Kabashima K., Ogawa J., *Kunisawa J. 17(S),18(R)-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression. FASEB Bioadv 2 (1), 59-71, 2019
  • Tada R., Ohshima A., Tanazawa Y., Ohmi A., Takahashi S., Kiyono H., Kunisawa J., Aramaki Y., Negishi Y. Essential role of host double-stranded DNA released from dying cells by cationic liposomes for mucosal adjuvanticity, Vaccines (Basel) 8(1): pii: E8, 2019
  • Sawane K., Nagatake T., Hosomi K., Hirata S.I., Adachi J., Abe Y., Isoyama J., Suzuki H., Matsunaga A., Fukumitsu S., Aida K., Tomonaga T., Arita M., *Kunisawa J. Dietary omega-3 fatty acid dampens allergic rhinitis via eosinophilic production of the anti-allergic lipid mediator 15-hydroxyeicosapentaenoic acid in mice, Nutrients 11(12): E2868, 2019
  • Yamada T., Hino S., Iijima H., Genda T., Aoki R., Nagata R., Han K.H., Hirota M., Kinashi Y., Oguchi H., Suda W., Furusawa Y., Fujimura Y., Kunisawa J., Hattori M., Fukushima M., Morita T., Hase K., Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis, EBioMedicine pii: S2352-3964(19): 30606-1, 2019
  • Nishida K., Hasegawa A., Yamasaki S., Uchida R., Ohashi W., Kurashima Y., Kunisawa J., Kimura S., Iwanaga T., Watarai H., Hase K., Ogura H., Nakayama M., Kashiwakura J.I., Okayama Y., Kubo M., Ohara O., Kiyono H., Koseki H., Murakami M., Hirano T., Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis, Sci Rep 9(1): 10842, 2019
  • Lan H, Hosomi K, *Kunisawa J, Clostridium perfringens enterotoxin-based protein engineering for the vaccine design and delivery system, Vaccine 37(42): 6232-6239, 2019
  • Hashimoto Y., Tachibana K., Krug S.M., Kunisawa J., Fromm M., Kondoh M., Potential for tight junction protein-directed drug development using claudin binders and angubindin-1, Int J Mol Sci 20(16): E4016, 2019
  • Nagatake T, *Kunisawa J., Emerging roles of metabolites of ω3 and ω6 essential fatty acids in the control of intestinal inflammation, Int Immunol 23;31(9):569-577, 2019
  • Nagatake T., Hirata S.I., Koga T., Kuroda E., Kobari S., Suzuki H., Hosomi K., Matsumoto N., Yanrismet Y., Shimojou M., Morimoto S., Sasaki F., Ishii K.J., Yokomizo T., and *Kunisawa J., BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses, Mucosal Immunol 12(5):1082-1091, 2019
  • Takahashi Y., Park J., Hosomi K., Yamada T., Kobayashi A., Iketani S., Kunisawa J., Mizuguchi K., Maeda N., and Ohshima T., Analysis of oral microbiota in Japanese oral cancer patients using 16S rRNA sequencing, J Oral Biosci 61(2): 120-128, 2019
  • Tiwari P., Nagatake T., Hirata S. I., Sawane K., Saika A., Shibata Y., Morimoto S., Honda T., Adachi J., Abe Y., Isoyama J., Tomonaga T., Kiyono H., Kabashima K., and *Kunisawa J., Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice. Allergy 74(8): 1522-1532, 2019 　
  • Yamasaki-Yashiki S.., Miyoshi Y., Nakayama T.,Kunisawa J., and Katakukra Y. IgA-enhancing effects of membrane vesicles derived from Lactobacillus sakei subsp. sakei NBRC15893, Bioscience of Microbiota, Food and Health 38(1): 23-29, 2019
  • Hosomi K., Hinenoya A., Suzuki H., Nagatake T., Nishino T., Tojima Y., Hirata S. I., Matsunaga A., Kondoh M., Yamasaki S., and *Kunisawa J., Development of a bivalent food poisoning vaccine: augmenting the antigenicity of Clostridium perfringens enterotoxin by fusion with the B subunit of Escherichia coli Shiga toxin 2, Int Immunol 31(2):91-100, 2019
  • Hosomi K., Kiyono H., *Kunisawa J., Fatty acid metabolism in the host and commensal bacteria for the control of intestinal immune responses and diseases, Gut Microbes 23: 1-9, 2019
  • Yoshii K., Hosomi K., Sawane K., and *Kunisawa J., Metabolism of dietary and microbial vitamin B family in the regulation of host immunity, Front Nutr 6:48, 2019
  • Saika A., Nagatake T., and *Kunisawa J., Host- and microbe-dependent dietary lipid metabolism in the control of allergy, inflammation and immunity, Front Nutr 6: 36, 2019
  • Suzuki H., and *Kunisawa J., Influence of dietary components and commensal bacteria on the control of mucosal immunity, Mucosal Vaccines: Innovation for Preventing Infectious Diseases 2nd edition (Edited by Hiroshi Kiyono & David Pascual), Elsevier, 2019
  • Nagatake T., *Kunisawa J., and Kiyono H., Lymphoid tissues associated with gastrointestinal (GI) mucosa, Lymph Node Metastasis in Gastrointestinal Cancerpp. 111-126, (Edited by Shoji Natsukoshi), Springer, 2019
  • 吉井健、細見晃司、國澤純　腸内細菌を介した免疫制御と生体防御　 臨床とウイルス47(4): 194-201, 2019
  • 細見晃司、國澤純　次世代ワクチンの開発に向けたワクチンマテリアルの創出と将来展望　ファルマシア55(11): 1058-1062, 2019
  • 平田宗一郎、國澤純　マイクロバイオーム研究からのワクチン開発　 Precision Medicine 2(10): 30-33, 2019
  • 長竹貴広、國澤純　食用油の脂肪酸組成のユニーク性を利用した多臓器アレルギー・炎症疾患の制御　 実験医学増刊 新時代が始まった－アレルギー疾患研究 37(10): 113-120, 2019
  • 國澤純　腸を起点に形成される免疫環境の理解とヘルスケアへの新展開 　 バイオサイエンスとインダストリー 77(3): 254-255, 2019
  • 細見晃司、國澤純　栄養学と腸内細菌から考える個別化医療の将来展望 　 Precision Medicine 2(4): 14-17, 2019
  • 雑賀あずさ、國澤純　食用油を起点とした脂質代謝と腸内細菌叢の変動を介した宿主免疫制御　 オレオサイエンス 19(4): 153-160, 2019
  • 國澤純　食から生体機能に繋がる分子メカニズムの理解と応用　 実験医学 37(4): 496-501, 2019
  • 長竹貴広、國澤純　食用油を起点に形成される脂質ネットワークと免疫制御　 実験医学 37(4): 502-507, 2019
  • 細見晃司、國澤純　油と腸内フローラから考える健康科学の新展開　 イルシー 137: 16-24, 2019
  • 長竹貴広、國澤純　健康状態を左右する腸内環境因子としての食事と腸内細菌叢　 Cardiac Practice 29(4): 45-49, 2019

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2018

  • Suzuki H., Hosomi K., Nasu A., Kondoh M., and *Kunisawa J., Development of adjuvant-free bivalent food poisoning vaccine by augmenting the antigenicity of Clostridium perfringens enterotoxin, Front Immunol 9:2320, 2018
  • Tada R, Yamanaka D, Ogasawara M, Saito M, Ohno N, Kiyono H, Kunisawa J, Aramaki Y, Polymeric caffeic acid is a safer mucosal adjuvant that augments antigen-specific mucosal and systemic immune responses in mice, Mol Pharm 15(9): 4226-4234, 2018
  • Nagatake T, Suzuki H, Hirata S.I, Matsumoto N, Wada Y, Morimoto S, Nasu A, Shimojou M, Kawano M, Ogami K, Tsujimura Y, Kuroda E, Iijima N, Hosomi K, Ishii K.J, Nosaka T, Yasutomi Y, Kunisawa J*, Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice, Int Immunol 30(10):471-481, 2018
  • Tada R, Hidaka A, Kiyono H, Kunisawa J, and Aramaki Y, Intranasal administration of cationic liposomes enhanced granulocyte-macrophage colony-stimulating factor expression and this expression is dispensable for mucosal adjuvant activity, BMC Research Notes 11(1):472, 2018
  • Tada R, Suzuki H, Takahashi S, Negishi Y, Kiyono H, Kunisawa J, and Aramaki Y, Nasal vaccination with Pneumococcal Surface Protein A in combination with cationic liposomes consisting of DOTAP and DC-chol confers antigen-mediated protective immunity against Streptococcus pneumoniae infections in mice, Int Immunopharm 61:385-393, 2018
  • Matsuzaki C, Takagaki C, Higashimura Y, Nakashima Y, Hosomi K, Kunisawa J, Yamamoto K, Hisa K, Immunostimulatory effect on dendritic cells of the adjuvant-active exopolysaccharide from Leuconostoc mesenteroides strain NTM048, Biosci Biotechnol Biochem 4: 1-5, 2018
  • Sasaki A, Nagatake T (co-first author), Egami R, Gu G, Takigawa I, Ikeda W, Nakatani T, Kunisawa J, Fujita Y, Obesity suppresses cell-competition-mediated apical elimination of RasV12-rransformed cells from epithelial tissues, Cell Rep 23(4):974-982, 2018
  • Suzuki H, Nagatake T, Nasu A, Lan H, Ikegami K, Setou M, Hamazaki Y, Kiyono H, Yagi K, Kondoh M, and Kunisawa J*, Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice, Sci Rep 8(1):2904, 2018
  • Shibata N, Kunisawa J*, Hosomi K, Fujimoto Y, Mizote K, Kitayama N, Shimoyama A, Mimuro H, Sato S, Kishishita N, Ishii KJ, Fukase K, and Kiyono H, Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity, Mucosal Immunol 11(3):693-702, 2018
  • Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, and Kunisawa J*, 17,18-EpETE–GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques, J Allergy Clin Immunol 142(2): 470-484, 2018
  • 雑賀あずさ、國澤純　腸管における脂質代謝物の産生とアレルギー疾患の制御　 四国医学雑誌 74: 137-146, 2018
  • 長竹貴広、國澤純　免疫・ワクチン応答を左右する腸内環境因子としての栄養と腸内細菌　 別冊・医学のあゆみ 43-50, 2018 　　　　　　
  • 雑賀あずさ、國澤純　食用油を介した「食事－腸内細菌－宿主」ネットワークによる免疫制御　 腸内細菌学雑誌 32: 167-174, 2018
  • 松永安由、國澤純　健康長寿の実現を目指した腸内環境の理解と将来展望　 食品と開発 53(10): 8-11, 2018
  • 長竹貴広、國澤純　マウスとカニクイザルにおいて17,18-EpETEは好中球のGPR40を介した遊走抑制によって接触皮膚炎を改善する　 臨床免疫・アレルギー科 70(2): 145-149, 2018
  • 澤根健人、國澤純　食事性脂肪酸およびその代謝物によるアレルギー疾患の制御　 医学のあゆみ 264(11): 961-965, 2018
  • 長竹貴広、國澤純　脂肪酸代謝物による腸管・皮膚アレルギーの制御　 細胞 50(3), 127-131, 2018
  • 松永安由、國澤純　アレルギー疾患における腸内環境の影響と健康科学への展開　 職業・環境アレルギー学会誌 25(2): 1-7, 2018　
  • 平田宗一郎、國澤純　マイクロバイオーム・感染症研究からのワクチン開発への展望　 最新医学 73a(4): 93-97, 2018
  • 細見晃司、國澤純　ヒトマイクロバイオームビッグデータと健康医療への応用　 月刊化学工業 69(3): 41-47, 2018
  • 長竹貴広、國澤純　免疫・ワクチン応答を左右する腸内環境因子としての栄養と腸内細菌　 医学のあゆみ 264(5): 403-410, 2018
  • 鈴木英彦、國澤純　ワクチンデリバリーを基盤とした粘膜ワクチン開発　 Drug Delivery System 33(1): 43-49, 2018
  • 細見晃司、國澤純　腸内環境に関連するビッグデータの集積と創薬、機能性食品開発への展望　 腸内細菌叢を標的にした医薬品と保健機能食品の開発 3-10, 2018
  • 平田宗一郎、國澤純　経粘膜ワクチンデリバリー製剤の開発と今後の展望　 ドラッグデリバリーシステム－バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発（監修、杉林堅次） 2018

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2017

  • Nakamizo S, Honda T, Adachi A, Nagatake T, Kunisawa J, Kitoh A, Otsuka A, Dainichi T, Nomura T, Ginhoux F, Ikuta K, Egawa G, Kabashima K, High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells, Sci Rep 7(1):14076, 2017
  • Sasakawa Y, Kominami A, Abe M, Yamamoto K, Nakao M, Nakaoka F, Okumura S, Juneja L.R, and Kunisawa J, The anti-obesity and anti-inflammatory effects of “LICONINE™”, an extract of glycyrrhiza uralensis, on diet-induced obese mice and 3T3-L1 mouse adipocytes, J Food Nut Res 5(10): 781-788, 2017
  • Takigawa M, Iida M, Nagase S, Suzuki H, Watari A, Tada M, Okada Y, Doi T, Fukasawa M, Yagi K, Kunisawa J, and Kondoh M, Creation of a claudin-2 binder and its tight-junction-modulating activity in a human intestinal model,J Pharmacol Exp Ther 363 (3): 444-451, 2017
  • Shibata N, Kunisawa J*, and Kiyono H, Dietary and microbial metabolites in the regulation of host immunity, Front Microbiol 8: 2171, 2017
  • Matsuzakia C, Takagaki C, Tomabechi Y, Forsberg LS, Heiss C, Azadi P, Matsumoto K, Katoh T, Hosomi K, Kunisawa J, Yamamoto K, Hisa K, Structural characterization of the immunostimulatory exopolysaccharide produced by Leuconostoc mesenteroides strain NTM048, Carbohydr Res 448: 95-102, 2017
  • Hosomi K, Ohno H, Murakami H, Natsume-Kitatani Y, Tanisawa K, Hirata S, Suzuki H, Nagatake T, Nishino T, Mizuguchi K, Miyachi M, and Kunisawa J*, Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity, Sci Rep 7(1): 4339, 2017
  • Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams I, Kiyono H, and Ohno H, IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake, J Exp Med 214(6): 1607-1618, 2017
  • Hirata S and Kunisawa J*, Gut microbiome, metabolome, and allergic diseases, Allergol Int S1323-8930(17) 30086-2, 2017
  • Hosomi K and Kunisawa J*, The specific roles of vitamins in the regulation of immunosurveillance, allergy, and inflammation in the gut, Immune Netw 17: 13-19, 2017
  • Kunisawa J*, Metabolic changes during B cell differentiation for the production of intestinal IgA antibody, Cell Mol Life Sci 74(8):1503-1509, 2017
  • Tada R, Muto S, Iwata T, Hidaka A, Kiyono H, Kunisawa J, Aramaki Y, Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice, BMC Res Notes 10(1): 68, 2017
  • 松永安由、國澤純　腸内フローラや食品成分を介した免疫グロブリンA産生制御　 Clinical Neuroscience 35(11): 1285-1287, 2017
  • 平田宗一郎、國澤純　腸内環境を介したリポクオリティの形成とアレルギー疾患の制御 アレルギーの臨床 37(129): 49-52, 2017
  • 澤根健人、國澤純　食用油を起点に形成される生体内脂質環境の構築とアレルギー疾患の制御 実験医学増刊 35(7): 185-190, 2017
  • 粕渕真由、木村郁夫、國澤純　腸内環境と腸管免疫・生体防御に関する新しいトピックス 消化と吸収 39(2): 66-70, 2017
  • 細見晃司、國澤純　アジュバントのターゲットとしての粘膜免疫システム　 次世代アジュバント開発のためのメカニズム解明と安全性評価（監修、石井健）26-33, 2017
  • 長竹貴宏、國澤純　食物アレルギーの発症における食用油クオリティの影響 ～油の質がアレルギー体質を決める！？～ 化学と生物55(1): 11-12, 2017
  • 鈴木英彦、國澤純　ビタミンによる免疫応答の制御と疾患 炎症と免疫 25(1): 29-33, 2017

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2016

  • E. Kuroda, K. Ozasa, B. Temizoz, K. Ohata, C.X. Koo, T. Kanuma, T. Kusakabe, S. Kobari, M. Horie, Y. Morimoto, S. Nakajima, K. Kabashima, S.F. Ziegler, Y. Iwakura, W. Ise, T. Kurosaki, T. Nagatake, J. Kunisawa, N. Taketomi, S. Uematsu, M. Hayashi, T. Aoshi, K. Kobiyama, C. Coban, K.J. Ishii, Inhaled fine particles induce alveolar macrophage death and interleukin 1α release to promote inducible bronchus-associated lymphoid tissue formation, Immunity 45(6):1299-1310, 2016
  • M. Yoshida, N. Kamei, K. Muto, J. Kunisawa, K. Takayama, N.A. Peppas, M. Takeda-Morishita, Complexation hydrogels as potential carriers in oral vaccine delivery systems, Eur J Pharm Biopharm pii: S0939-6411(16)30872-4, 2016
  • J. Kunisawa* and H. Kiyono, Sphingolipids and epoxidized lipid metabolites in the control of gut immunosurveillance and allergy, Front Nutrition 3:3, 2016
  • T.C. Fung, N.J. Bessman, M.R. Hepworth, N. Kumar, N. Shibata, D. Kobuley, K. Wang, C.G. Ziegler, J Goc, T. Shima, Y. Umesaki, R.B. Sartor, K.V. Sullivan, T.D Lawley, J. Kunisawa, H. Kiyono, G.F. Sonnenberg, Lymphoid tissue-resident commensal bacteria promote members of the IL-10 cytokine family to establish mutualism, Immunity 15;44(3):634-46, 2016
  • J. Kunisawa*, Immunity and Nutrition,Encyclopedia of Immunology vol. 5, pp. 120-126, (Edited by Michael J.H. Ratcliffe), Academic Press, Oxford, UK, 2016
  • 國澤純　腸内環境を介した免疫制御とアレルギー・炎症との関連　Labcab 17:5-7, 2016
  • 平田宗一郎、國澤純　脂質を介した腸管免疫の制御と疾患・生体防御　生体の科学 67(3): 242-246, 2016
  • 國澤純　食事性脂質を介した腸管免疫ネットワークの形成　JATAFFジャーナル 4(5): 64, 2016
  • 平田宗一郎、國澤純　動物モデルを用いた食物アレルギーの発症機序の解明と予防・治療法の開発に向けた研究展開　アレルギーの臨床 36: 37-40, 2016
  • 國澤純、平田宗一郎、清野宏　経粘膜ワクチンデリバリー製剤の開発の現状と今後の展望　薬剤学 76: 11-17, 2016
  • 細見晃司、國澤純　腸内細菌と粘膜免疫　ヒトマイクロバイオーム研究最前線119-128, 2016
  • 細見晃司、國澤純　マイクロバイオームとワクチン開発 ヒトマイクロバイオーム研究最前線 253: 451-456, 2016

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2015

  • Y. Goto, A. Lamichhane, M. Kamioka, S. Sato, K. Honda, J. Kunisawa*, H. Kiyono, IL-10-producing CD4+ T cells negatively regulate fucosylation of epithelial cells in the gut, Sci Rep 5:15918, 2015
  • R. Tada, A. Hidaka, N. Iwase, S. Takahashi, Y. Yamakita, T. Iwata, S. Muto, E. Sato, N. Takayama, E. Honjo, H. Kiyono, J. Kunisawa, and Y. Aramaki, Intranasal immunization with DOTAP cationic liposomes combined with DC-cholesterol induces potent antigen-specific mucosal and systemic immune responses in mice, PLoS ONE 10:e0139785, 2015
  • J. Kunisawa*, Y. Sugiura, T. Wake, T. Nagatake, H. Suzuki, R. Nagasawa, S. Shikata, K. Honda, E. Hashimoto, Y. Suzuki, M. Setou, M. Suematsu, H. Kiyono, Mode of bioenergetic metabolism during B cell differentiation in the intestine determines the distinct requirement for vitamin B1, Cell Rep 13:122-131, 2015
  • H. Suzuki, A. Watari, E. Hashimoto, M. Yonemitsu, H. Kiyono, K. Yagi, M. Kondoh, and J. Kunisawa*, C-terminal Clostridium perfringens enterotoxin-mediated antigen delivery for nasal pneumococcal vaccine, PLoS ONE 10(5):e0126352, 2015
  • T. Nagatake, S. Fukuyama, S. Sato, H. Okura, M. Tachibana, I. Taniuchi, K. Ito, M. Shimojou, N. Matsumoto, H, Suzuki, J. Kunisawa, and H. Kiyono, Central role of core binding factor β2 in mucosa-associated lymphoid tissue organogenesis in mouse, PLoS ONE 10(5):e0127460, 2015
  • J. Kunisawa*, M. Arita, T. Hayasaka, T. Harada, R. Iwamoto, R. Nagasawa, S. Shikata, T. Nagatake, H. Suzuki, E. Hashimoto, Y. Kurashima, Y. Suzuki, H. Arai, M. Setou, and H. Kiyono, Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut, Sci Rep 5:9750, 2015
  • K. Kishita, M. Kohyama, Y. Kurashima, Y. Kogure, J. Wang, K. Hirayasu, T. Suenaga, H. Kiyono, J. Kunisawa, and H. Arase, Negative regulation of DSS-induced experimental colitis by PILRα, Int Immunol 27: 307-14, 2015
  • M. Sanosaka, M. Fujimoto, T. Ohkawara, T. Nagatake, Y. Itoh, M. Kagawa, A. Kumagai, H. Fuchino, J. Kunisawa, T. Naka, H. Takemori, SIK3 deficiency exacerbates LPS-induced endotoxin shock accompanied by increased levels of proinflammatory molecules in mice, Immunology 145(2):268-78, 2015
  • F. Suenaga, S. Ueha, J. Abe, M. Kosugi-Kanaya, Y. Wang, A. Yokoyama, Y. Shono, F.H. Shand, Y. Morishita, J. Kunisawa, S. Sato, H. Kiyono, and K. Matsushima, Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease, J Immunol 194: 398-406, 2015
  • H. Suzuki and J. Kunisawa*, Vitamin-mediated immune regulation in the development of inflammatory diseases, Endocrine, Metabolic & Immune Disorders - Drug Targets 15:212-215, 2015
  • Y. Kurashima, H. Kiyono, and J. Kunisawa*, Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation, Mediators of Inflammation 2015: 427125, 2015
  • J. Kunisawa* and H. Kiyono, Vitamins mediate immunological homeostasis and diseases at the surface of the body, Endocrine, Metabolic & Immune Disorders - Drug Targets 15: 25-30, 2015
  • J. Kunisawa*, Vitamin B9 and ATP in the control and development of intestinal inflammation, Inflammation and Regeneration 35: 14-18, 2015
  • J. Kunisawa*, Immunity and Nutrition, Encyclopedia of Immunology (Edited by Michael J.H. Ratcliffe) Elsevier, Kindlington, UK (in press)
  • 國澤純、平田宗一郎、清野宏　経粘膜ワクチンデリバリー製剤の開発の現状と今後の展望　薬剤学 2015(印刷中)
  • 細見晃司、國澤純　腸管免疫に関与するMAIT細胞のユニークな機能　炎症と免疫 23:23-28,2015
  • 長竹貴広、國澤純　脂質を介した腸管免疫の制御と疾患　実験医学 33:94-99,2015
  • 細見晃司、國澤純　粘腸管での多元的免疫ネットワークを介した生体防御と疾患家畜感染症学会誌 4: 21-28, 2015
  • 長竹貴広、國澤純　腸管組織における多元的免疫制御システムと食物アレルギー　医学のあゆみ 253: 451-456, 2015
  • 鈴木英彦、國澤純　粘膜免疫の特異性に着目したワクチンマテリアルの開発　感染・炎症・免疫 45: 49-55, 2015

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2014

  • Y. Goto, T. Obata, J. Kunisawa, S. Sato, I. I. Ivanov, A. Lamichhane, N. Takeyama, M. Kamioka, M. Sakamoto, T. Matsuki, H. Setoyama, A. Imaoka, S. Uematsu, S. Akira, S. E. Domino, P. Kulig, B. Becher, J. Renauld, C. Sasakawa, Y. Umesaki, Y. Benno, and H. Kiyono, Innate lymphoid cells govern intestinal epithelial fucosylation, Science 345(6202):1254009, 2014
  • A. Sato, A. Suwanto, M. Okabe, S. Sato, T. Nochi, T. Imai, N. Koyanagi, J. Kunisawa, Y. Kawaguchi, and H. Kiyono, Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease, J Virol 88(23):13699-708, 2014
  • H. Nakajima-Adachi, A. Kikuchi, Y. Fujimura, K. Shibahara, T. Makino, M. Goseki-Sone, M. Kihara-Fujioka, T. Nochi, Y. Kurashima, O. Igarashi, M. Yamamoto, J. Kunisawa, M. Toda, S. Kaminogawa, R. Sato, H. Kiyono, S. Hachimura, Peyer’s patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy, PLoS ONE 9(10):e107492, 2014
  • J. Kunisawa*, E. Hashimoto, A. Inoue, R. Nagasawa, Y. Suzuki, I.Ishikawa, S. Shikata, M. Arita, J. Aoki, and H. Kiyono, Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism, J Immunol 193:1666-1671,2014
  • Y. Kurashima, T. Amiya, K. Fujisawa, N. Shibata, Y. Suzuki, Y. Kogure, E. Hashimoto, A. Otsuka, K. Kabashima, S. Sato, T. Sato, M. Kubo, S. Akira, K. Miyake, J. Kunisawa*, and H. Kiyono, The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis, Immunity 40:530-41,2014
  • N. Takemura, T. Kawasaki, J. Kunisawa, S. Sato, L. Aayam, K. Kobiyama, T. Aoshi, J. Ito, K. Mizuguchi, T. Karuppuchamy, K. Matsunaga, S. Miyatake, N. Mori, T. Tsujimura, T. Satoh, Y. Kumagai, T. Kawai, D. Standley, K. Ishii, H. Kiyono, S. Akira, and S. Uematsu, Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome, Nat Commun 5: 3492, 2014
  • Y. Kotani, J. Kunisawa*, Y. Suzuki, I. Sato, T. Saito, M. Toba, N. Kohda, and H. Kiyono, Role of Lactobacillus pentosus strain b240 and the Toll-like receptor 2 axis in Peyer’s patch dendritic cell-mediated immunoglobulin A enhancement, PLoS One 9(3):e91857, 2014
  • 鈴木英彦、國澤純　CD11b陽性IgA産生細胞の誘導と機能 臨床免疫・アレルギー科62: 552-556, 2014
  • 倉島洋介、佐藤健、清野宏、國澤純　DAMPsによるマスト細胞の活性化と疾患 臨床免疫・アレルギー科 62: 675-679, 2014
  • 倉島洋介、清野宏、國澤純　細胞外核酸を介したマスト細胞の活性化と炎症性腸疾患 生化学 86: 798-802, 2014
  • 高里良宏、倉島洋介、清野宏、國澤純　抑制型免疫システムを応用した次世代型抗アレルギーワクチンの開発 Bioindustry 6,55-60,2104
  • 鈴木英彦、國澤純　粘膜免疫システムの多面的機能を応用したワクチン開発の現状と未来 The Frontiers in Life Sciences「生命科学からの創薬へのイノベーション」 57-62, 2014
  • 長竹貴広、國澤　純　 脂質を介した腸管免疫システムの制御 医学のあゆみ 248,1019-1024,2014
  • 近藤昌夫、國澤　純　 上皮細胞を標的とした創薬研究の新展開 薬学雑誌 134,613,2014
  • 鈴木英彦、近藤昌夫、八木清仁、清野宏、國澤　純　 微生物の有する粘膜組織指向性を用いた粘膜ワクチンデリバリー開発への展望 薬学雑誌 134,629-634,2014

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2013

  • S. Kishino, M. Takeuchia, S.B. Park, A. Hirata, N. Kitamura, J. Kunisawa, H. Kiyono, R. Iwamoto, Y. Isobe, M. Arita, H. Arai, K. Ueda, J. Shima, S. Takahashi, K. Yokozeki, S. Shimizu, and J. Ogawa, Novel fatty acid metabolism in gut lactic acid bacteria affecting host lipid composition, Proc Natl Acad Sci USA 110: 17808-17813, 2013
  • J. Kunisawa* and H. Kiyono, Vitamin-mediated regulation of intestinal immunity, Front in Immunol 4:189, 2013
  • T. Nagatake, and J. Kunisawa*, Unique functions of mucosa-associated lymphoid tissues as targets of mucosal vaccines, Curr Topics Pharmacol 17: 13-23, 2013
  • A. Lamichhane, H. Kiyono, and J. Kunisawa* , Nutritional components regulate the gut immune system and its association with intestinal immune disease development, J Gastroenterol Hepatol 28: 18-24, 2013
  • M. Kamioka, H. Kiyono, and J. Kunisawa*, Herbal medicine-initiated approaches for the elucidation of immunological network in the intestine, J Tradition Med 30:56-61,2013
  • T. Obata, N. Shibata, Y. Goto, I. Ishikawa, S. Sato, J. Kunisawa*, and H. Kiyono, Critical role of dendritic cells in T-cell retention in the interfollicular region of Peyer’s patches, J Immunol 191(2):942-8,2013
  • J. Kunisawa*, M. Gohda, E. Hashimoto, I. Ishikawa, M. Higuchi, Y. Suzuki, Y. Goto, C. Panea, I. I. Ivanov, R. Sumiya, L. Aayam, T.Wake, S. Tajiri, Y. Kurashima, S. Shikata, S. Akira, K. Takeda, and H. Kiyono, Microbe-dependent CD11b+ IgA+ plasma cells in early-phase robust intestinal IgA responses in mice, Nat Commun 4:1772, 2013
  • Y. Fukuyama, D. Tokuhara, S. Sekine, K. Aso, K. Kataoka, J. Davydova, M. Yamamoto, R.S. Gilbert, Y. Tokuhara, K. Fujihashi, J. Kunisawa, Y. Yuki, H. Kiyono, J.R. McGhee, K. Fujihashi, Potential roles of CCR5+ CCR6+ dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses, PLoS One 8:e60453, 2013
  • I. Kong, A. Sato, Y. Yuki, T. Nochi, H. Takahashi, S. Sawada, M. Mejima, S. Kurokawa, K. Okada, S. Sato, D. Briles, J. Kunisawa, Y. Inoue, M. Yamamoto, K. Akiyoshi, and H. Kiyono, Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by pneumococcus, Infection and Immunity 81: 1625-34, 2013
  • S. Sato, S. Kaneto, N. Shibata, Y. Takahashi, H. Okura, Y. Yuki, J. Kunisawa, and H. Kiyono, Transcription factor Spi-B–dependent and –independent pathways for the development of Peyer's patch M cells, Mucosal Immunol 6:838-46,2013
  • T. Kusu, H. Kayama, M. Kinoshita, S. G. Jeon, Y. Ueda, Y. Goto, R. Okumura, H. Saiga, T. Kurakawa, K. Ikeda, Y. Maeda, J. I. Nishimura, Y. Arima, K. Atarashi, K. Honda, M. Murakami, J. Kunisawa, H. Kiyono, M. Okumura, M. Yamamoto, and K. Takeda, Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 vell tesponses through regulation of luminal ATP in the small intestine, J Immunol 190:774-83, 2013
  • J. Kunisawa* and H. Kiyono, Immune regulation and surveillance at the epithelial surface of the intestine, Drug Discov Today 18:87-92, 2013
  • 國澤　純　東洋医学を起点とした粘膜免疫の基礎的解明と病態制御への展開　日本医科大学医学会雑誌9, 214-217, 2013
  • 鈴木英彦、國澤　純　 ビタミンを介した腸管免疫の制御と疾患　細胞45　12-16,2013
  • 田尻　創、清野　宏、國澤　純　　腸管免疫疾患における脂質メディエーター（監修　横溝岳彦、編集　青木淳賢、杉本幸彦、村上誠）　遺伝子医学MOOK　241-245, 2013
  • 倉島洋介、國澤　純、清野　宏　　粘膜マスト細胞と疾患　最新医学68巻3月増刊号自己免疫疾患・アレルギー疾患（前篇）免疫の基礎，検査，治療　704-727, 2013
  • 國澤　純　　粘膜における免疫ホメオスタシス、標準免疫学（監修　谷口克、編集　宮坂昌之、小安重夫）　医学書院　197-205, 2013 　　　　　
  • 國澤　純　　岩波生物学辞典 　 2013　

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2012

  • Y. Kurashima, T. Amiya, T. Nochi, K. Fujisawa, T. Haraguchi, H. Iba, H. Tsutsui, S. Sato, S. Nakajima, H. Iijima, M. Kubo, J. Kunisawa*, and H. Kiyono*, Extracellular ATP mediates mast cell–dependent intestinal inflammation through P2X7 purinoceptors, Nat Commun 3: 1034, 2012
  • M. Kinoshita, H. Kayama, T. Kusu, T. Yamaguchi, J. Kunisawa, H. Kiyono, S. Sakaguchi, and K. Takeda, Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon, J Immunol 189: 2689-78, 2012
  • T. Shibata, N. Takemura, Y. Motoi, Y. Goto, T. Karuppuchamy, K. Izawa, X. Li, S. Akashi-Takamura, N. Tanimura, J. Kunisawa, H. Kiyono, S. Akira, T. Kitamura, J. Kitaura, S. Uematsu, K. Miyake, PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells, Int Immunol 24:613-23, 2012
  • G. F. Sonnenberg, L. A. Monticelli, T. Alenghat, T. C. Fung, N. A. Hutnick, J. Kunisawa, N. Shibata, S. Grunberg, R. Sinha, A. M. Zahm, M. R. Tardif, T. Sathaliyawala, M. Kubota, D. L. Farber, R. G. Collman, A. Shaked, L. A. Fouser, D. B. Weiner, P. A. Tessier, J. R. Friedman, H. Kiyono, F. D. Bushman, K. Chang, and D. Artis, Innate lymphoid cells orchestrate anatomical containment of lymphoid-resident commensal bacteria and prevent systemic immune activation, Science 336(6086):1321-5, 2012
  • S. Tanaka, Y. Saito, J. Kunisawa, Y. Kurashima, T. Wake, N. Suzuki, L. D. Shultz, H. Kiyono, and F. Ishikawa, Development of mature and functional human myeloid subsets in HSC engrafted NOD/SCID/IL2rγ KO mice, J Immunol 188:6145-55, 2012
  • J. Kunisawa*, E. Hashimoto, I. Ishikawa, and H. Kiyono, A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo, PLoS One 7: e32094, 2012
  • S. Takagi, Y. Saito, A. Hijikata, S. Tanaka, T. Watanabe, T. Hasegawa, S. Mochizuki, J. Kunisawa, H. Kiyono, H. Koseki, O. Ohara, T. Saito, S. Taniguchi, L. D. Shultz, F. Ishikawa, Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood 119: 2768-77, 2012
  • J. Kunisawa* and H. Kiyono, Alcaligenes is commensal bacteria habituating in the gut-associated lymphoid tissue for the regulation of intestinal IgA responses. Front in Immunol 3 (65): 1-5, 2012
  • J. Kunisawa* and H. Kiyono, Immunological function of sphingosine 1-phosphate in the intestine. Nutrients 4: 154-166, 2012
  • J. Kunisawa*, Y. Kurashima, and H. Kiyono, Gut-associated lymphoid tissues for the development of oral vaccine. Adv Drug Deliv Rev 64: 523-30, 2012
  • D.Y. Kim, S. Fukuyama, T. Nagatake, K. Takamura, I.G. Kong, Y. Yokota, C.H. Lee, and H. Kiyono. Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model. Allergy, 67 (4), 502-9, 2012
  • 柴田納央子、國澤純、清野宏　自然リンパ球はリンパ組織内共生細菌の解剖学的な隔離を促進する　細胞工学　31: 1256-1257, 2012
  • 國澤　純、清野　宏　実用化ステージとなった粘膜ワクチンの今後に向けた新展開　実験医学増刊号「感染・共生・防御の研究最前線」30: 3348-3353, 2012
  • 國澤　純、柴田納央子、清野　宏　腸管関連リンパ組織内における共生細菌との免疫学相互作用　医学のあゆみ 241: 181-185, 2012
  • 國澤　純　粘膜ワクチンの現状と未来　ドラッグデリバリーシステムの新展開II　149-154, 2012
  • 國澤　純　免疫学Update 分子病態の解明と治療への展開（審良静男、熊ノ郷淳、竹田潔、編）　2012

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2011

  • D. Y., Kim, A. Sato, S. Fukuyama, H. Sagara, T. Nagatake, I. G. Kong, K. Goda, T. Nochi, J. Kunisawa, S. Sato, Y. Yokota, C. H. Lee, and H. Kiyono, The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J Immunol 186: 4253-62,2011
  • J. Kunisawa* and H. Kiyono, Peaceful mutualism in the gut: Revealing key commensal bacteria for the creation and maintenance of immunological homeostasis. Cell Host Microbe 9: 83-84, 2011
  • M. Ogawa, Y. Yoshikawa, T. Kobayashi, H. Mimuro, M. Fukumatsu, K. Kiga, Z. Piao, H. Ashida, M. Yoshida, S. Kakuta, T. Koyama, Y. Goto, T. Nagatake, S. Nagai, H. Kiyono, M. Kawalec, J.M. Reichhart, C. Sasakawa. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe, 9 (5): 376-89, 2011
  • 和氣太一、國澤　純、清野　宏　粘膜表層における生体防御システムとしての粘膜免疫機能　表面 49: 13-22, 2011
  • 國澤　純　IgA産生における腸内免疫ネットワーク　実験医学増刊　免疫記憶の制御と疾患治療 29: 100-105, 2011
  • 國澤　純、後藤義幸、小幡高士、清野　宏　腸内細菌のパイエル板組織内共生　細胞工学 30: 409-412, 2011
  • 國澤　純　マクロ共焦点顕微鏡を用いた粘膜組織における細胞動態　Drug Delivery System 26: 419-421, 2011
  • 倉島洋介、網谷岳朗、國澤　純、清野　宏　食物アレルギーの予防および治療的戦略の確立に向けた粘膜免疫研究の展開　アレルギー免疫 18: 66-77, 2011
  • 國澤　純　自然免疫　腸内共生系のバイオサイエンス　－腸内細菌と免疫の関係－（財団法人日本ビフィズス菌センター、編）編集委員・執筆 2011
  • 高橋一郎、長竹貴広、清野宏　粘膜免疫システム：分子レベルで明らかになってきた監視・排除・共生機構と腸内細菌の全貌「基礎の基礎」細胞工学 30 (4): 342-7, 2011（秀潤社）
  • 長竹貴広、清野宏　粘膜関連リンパ組織　免疫の辞典 (桂義元、河本宏、小安重夫、山本一彦、編) 2011（朝倉書店）

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2010

  • T. Obata, Y. Goto, J. Kunisawa, S. Sato, M. Sakamoto, H. Setoyama, T. Matsuki, K. Nonaka, N. Shibata, M. Gohda, Y. Kagiyama, T. Nochi, Y. Yuki, Y. Fukuyama, A. Mukai, S. Shinzaki, K. Fujihashi, C. Sasakawa, H. Iijima, M. Goto, Y. Umesaki, Y. Benno, and H. Kiyono, Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proc Natl Acad Sci USA 107:7419-24, 2010
  • H. Kayamuro, Y. Yoshioka, Y. Abe, S. Arita, K. Katayama, T. Nomura, T. Yoshikawa, R. Kubota-Koketsu, K. Ikuta, S. Okamoto, Y. Mori, J. Kunisawa, H. Kiyono, N. Itoh, K. Nagano, H. Kamada, Y. Tsutsumi, S.I. Tsunoda, Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol 84: 12703-12, 2010
  • J. Kunisawa and H. Kiyono, Aberrant interaction of gut immune system with environmental factors in the development of food allergy. Curr Aller Asthma Rep 10: 215-221, 2010
  • J. Kunisawa, and H. Kiyono, Analysis of intestinal T cell populations and cytokine productions. Methods in Microbiology (Edited by Stefan H.E. Kaufmann and Dieter Kabelitz). Academic Press, Oxford, pp. 183-193, 2010
  • 國澤　純　腸管の生体防御や恒常性維持における脂質メディエーター：スフィンゴシン１リン酸の役割　化学と生物 48: 827-830, 2010
  • 國澤　純　粘膜免疫の新展開－生体最前線における腸内環境との調和と排除－　無菌生物 40, 25-28, 2010
  • 國澤　純　粘膜免疫におけるダイナミックな細胞移動－脂質メディエーターの関与－　臨床粘膜免疫学（清野　宏、編） p236-244, 2010
  • 福山聡、長竹貴広、清野宏　粘膜関連リンパ組織の特徴と組織構築分子基盤：鼻咽頭関連リンパ組織（NALT）臨床粘膜免疫学（清野宏、編）, 164-70, 2010.
  • 佐藤慎太郎、長竹貴広、清野宏　粘膜関連リンパ組織の特徴と組織構築分子基盤：涙道関連リンパ組織（TALT）臨床粘膜免疫学（清野宏、編）, 171-5, 2010.

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2009

  • T. Nagatake, S. Fukuyama, D. Y. Kim, K. Goda, O. Igarashi, S. Sato, T. Nochi, H. Sagara, Y. Yokota, A. M. Jetten, T. Kaisho, S. Akira, H. Mimuro, C. Sasakawa, Y. Fukui, K. Fujihashi, T. Akiyama, J. Inoue, J. M. Penninger, J. Kunisawa, and H. Kiyono, Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med 206:2351-2364, 2009
  • D. Kim, S. H. Kim, E. J. Park, J. Kim, S. H. Cho, J. Kagawa, N. Arai, J. Kunisawa, H. Kiyono, and S. Kim, Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Arcinidia arguta. Int Arch Allergy Immunol 12:164-171, 2009
  • S. Fukuyama, T. Nagatake, and H. Kiyono. Mucosa-associated lymphoid tissue and dynamics of lymphoid cells in the five different compartments in allergic diseases. Allergy Frontiers: Classification and Pathomechanisms (R. Pawankar, S.T. Holgate, L.J. Rosenwasser Editors), Volume 2, 563-601, Springer 2009.
  • 國澤　純　生態表面における免疫学的防御バリアを標的としたテクノロジー開発　表面 47: 13-19, 2009
  • 國澤　純　経鼻投与による気道炎症性疾患の制御は可能か？－粘膜免疫システムと粘膜免疫疾患－　耳鼻咽喉科展望 52: 19-23, 2009
  • 國澤　純、清野　宏　スフィンゴシン１リン酸と腸管免疫・炎症　炎症と免疫 17: 31-37, 2009
  • 國澤　純　粘膜ワクチンならびに粘膜免疫療法の開発に向けた研究動向　国際医薬品情報 888: 24-29, 2009
  • 國澤　純　スフィンゴシン１リン酸を介した腸管免疫制御機構の解明　腸内細菌学雑誌 23: 17-22, 2009

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2008

  • J. Kunisawa, M. Gohda, Y. Kurashima, I. Ishikawa, M. Higuchi, and H. Kiyono, Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFκB-inducing kinase in stromal cells. Blood 111: 4646-4652, 2008
  • M. Gohda, J. Kunisawa (contributed equally), F. Miura, Y. Kagiyama, Y. Kurashima, M. Higuchi, I. Ishikawa, I. Ogahara, and H. Kiyono, Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J Immunol 180: 5335-5343, 2008
  • J. Kunisawa, T. Nochi, and H. Kiyono, Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol 29: 505-513, 2008
  • H. Kiyono, J. Kunisawa, J. R. McGhee and J. Mestecky, The mucosal immune system. Fundamental Immunology (Edited by William E. Paul). Lippincott-Raven, Philadelphia, pp. 983-1030, 2008
  • 國澤　純、清野　宏　脂質メディエーターS1Pによる腸管免疫細胞の動態制御　感染・炎症・免疫 38: 20-27, 2008
  • 國澤　純、清野　宏　アレルギーと免疫寛容のパラドックス　細胞工学 27(8): 775-778, 2008
  • 國澤　純、清野　宏　食物アレルギーと粘膜免疫　臨床免疫・アレルギー科 49: 432-438, 2008
  • 國澤　純、清野　宏　DDS技術を基盤とした次世代型粘膜ワクチンの開発　Drug Delivery System 23(2): 116-122, 2008
  • 倉島洋介、國澤　純、清野　宏　粘膜免疫を介したアレルギー克服戦略　アレルギー 57(2): 87-94, 2008
  • 樋口森生、國澤　純、清野　宏　粘膜上皮細胞による上皮細胞間リンパ球（IEL）の反応制御　臨床免疫・アレルギー科 49: 16-21, 2008
  • 國澤　純、清野　宏　リンパ系の構築　改訂第２版　免疫学最新イラストレイテッド（小安重夫、編） p161-176, 2008

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2007

  • J. Kunisawa, Y. Kurashima, M. Higuchi, M. Gohda, I. Ishikawa, I. Ogahara, N. Kim, M. Shimizu, and H. Kiyono, Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med 204: 2335-2348, 2007
  • Y. Kurashima, J. Kunisawa, M. Higuchi, M. Gohda, I. Ishikawa, N. Takayama, M. Shimizu, and H. Kiyono, Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. J Immunol 179:1577-1585, 2007
  • J. Kunisawa, Y. Kurashima, M. Gohda, M. Higuchi, I. Ishikawa, F. Miura, I. Ogahara, and H. Kiyono, Sphingosine 1-phosphate regulates peritoneal B cell trafficking for subsequent intestinal IgA production. Blood 109:3749-3756, 2007
  • N. Kim, J. Kunisawa, M. N. Kweon, G. E. Ji, and H. Kiyono, Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4+ CD45RBhigh T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation. Clin Immunol 123:30-39, 2007
  • J. R. McGhee, J. Kunisawa, and H. Kiyono, Gut lymphocyte migration: We are halfway 'Home'. Trends Immunol 28:150-153, 2007
  • J. Kunisawa, I. Takahashi, and H. Kiyono, Intraepithelial lymphocytes: Their shared and divergent immunological behaviors in the small and large intestine. Immunol Rev 215:136-153, 2007
  • J. Kunisawa, J. R. McGhee, and H. Kiyono, Mucosal S-IgA enhancement: development of safe and effective mucosal adjuvants and mucosal antigen delivery vehicles. Mucosal Immune Defense: Immunoglobulin A (Edited by Charlotte S. Kaetzel), Kluwer Academic/Plenum Publishers, New York pp. 345-389, 2007
  • N. Tanaka, S. Fukuyama, T. Fukuiwa, M. Kawabata, Y. Sagara, H.O. Ito, Y. Miwa, T. Nagatake, H. Kiyono, and Y. Kurono. Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice. Vaccine, 25 (14): 2680-7, 2007
  • K. Takamura, S. Fukuyama, T. Nagatake, D.Y. Kim, A. Kawamura, H. Kawauchi, and H. Kiyono. Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. J. Immunol., 179 (9): 5897-906, 2007
  • 國澤　純、清野　宏　脂質メディエーターによる腸管免疫制御　実験医学　増刊 147-155, 2007
  • 國澤　純、清野　宏　粘膜免疫の分子生物学　The Frontiers in Medical Sciences 144-154, 2007
  • 國澤　純　抗原処理機構における細胞質シャペロンおよびERAAPの役割　Annual Review免疫　2007　24-35, 2007
  • 國澤　純、合田昌史、清野　宏　粘膜系免疫機構の解析と粘膜ワクチンの開発　薬学雑誌 127(2): 319-26, 2007
  • 福山聡、長竹貴広、清野宏 呼吸器関連リンパ組織の組織形成と免疫学的機能 実験医学増刊号 25 (20): 66-72, 2007（羊土社）

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2006

  • J. Kunisawa, and N. Shastri, Hsp90α chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway. Immunity 24:523-534, 2006
  • S. Fukuyama, T. Nagatake, D.Y. Kim, K. Takamura, E.J. Park, T. Kaisho, N. Tanaka, Y. Kurono, and H. Kiyono. Cutting edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. J Immunol, 177 (7): 4276-80, 2006
  • 國澤　純　でる？ or とどまる？ -スフィンゴシン１リン酸を介した免疫制御-　ファルマシア 42(11): 1158-1159, 2006
  • 國澤　純、清野　宏　粘膜免疫の分子生物学　免疫応答と免疫病態の統合的分子理解（谷口維紹、山本一彦、編） p144-153, 2007
  • 長竹貴広、福山聡、清野宏 粘膜免疫機構とケモカイ」 アレルギー・免疫 13 (1): 38-44, 2006（医薬ジャーナル社）
  • 長竹貴広、福山聡、清野宏 マウスにおけるNALT単核球分離法　日本免疫学会 Newsletter 14 (2): 21, 2006

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2005

  • J. Kunisawa, T. Masuda, K. Katayama, T. Yoshikawa, Y. Tsutsumi, M. Akashi, T. Mayumi, and S. Nakagawa, Fusogenic liposome delivers encapsulated nanoparticles for cytosolic controlled gene release. J Control Release 105:344-353, 2005
  • N. Shastri, S. Cardinaud, S. R. Schwab, T. Serwold, and J. Kunisawa, All the peptides that fit. The beginning, the middle, and the end of the MHC class I antigen processing pathway. Immunol Rev 207:31-41, 2005
  • J. Kunisawa, S. Fukuyama, and H. Kiyono, Mucosa-associated lymphoid tissues in aerodigestive tract: Their shared and divergent traits and their importance to the orchestration of mucosal immune system. Curr Mol Med 5:557-572, 2005
  • J. Kunisawa and H. Kiyono, A marvel of mucosal T cells and secretory antibodies to create important first lines of defense. Cell Mol Life Sci 62:1308-1321, 2005
  • 國澤　純　CTL誘導における抗原提示中間体形成機構の解明　感染・炎症・免疫 35(3): 60-63, 2005
  • 國澤　純　粘膜免疫の特徴と粘膜ワクチンの開発　生物工学会誌　83(5): 246, 2005
  • 倉島洋介、國澤　純、清野　宏　腸内感染防御システムとしての粘膜免疫　最新医学 増刊号115-123, 2005
  • 長竹貴広、福山聡、清野宏 NALTの形成とケモカイン 臨床免疫, 43 (1): 12-7, 2005（科学評論社）

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2004

  • S. Standley, Y. Kwon, N. Murthy, J. Kunisawa, N. Shastri, S. Guillaudeu, L. Lau, J. Frechet, Acid-degradable particles for protein-based vaccines: enhanced survival rate for tumor-challenged mice using ovalbumin model. Bioconjug Chem 15:1281-1288, 2004
  • T. Nochi, Y. Yuki, K. Terahara, A. Hino, J. Kunisawa, M. N. Kweon, T. Yamaguchi, and H. Kiyono, Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epithelium. Clin Immunol 113:326-339, 2004
  • M. H. Jang, M. N. Kweon, K. Iwatani, M. Yamamoto, K. Terahara, C. Sasakawa, T. Suzuki, T. Nochi, Y. Yokota, P. D. Rennert, T. Hiroi, H. Tamagawa, H. Iijima, J. Kunisawa, Y. Yuki, and H. Kiyono, Intestinal villous M cells: An antigen entry site in the mucosal epithelium. Proc Natl Acad Sci USA 101:6110-6115, 2004
  • 國澤　純　粘膜免疫システムを用いた粘膜ワクチンならびに免疫療法の開発　Drug Delivery System 19(4): 396-397, 2004
  • 國澤　純　MHC class I 拘束性抗原提示機構における細胞質内プロセッシングと小胞体内プロセッシング　Annual Review免疫2004　51-58, 2004
  • 國澤　純、真弓忠範　Drug Delivery Systemを用いた新規ワクチン開発　―ウイルスの技術利用―　わかる実験医学シリーズ：ウイルス・細菌と感染症がわかる 78-84, 2004
  • 長竹貴広、福山聡、清野宏　粘膜免疫と免疫寛容　アレルギー科, 18 (6): 467-75, 2004（科学評論社）

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2003

  • J. Kunisawa, and N. Shastri, The group II chaperonin TRiC protects proteolytic intermediates from degradation in the MHC class I antigen processing pathway. Mol Cell 12:565-576, 2003
  • N. Murthy, M. Xu, S. Schuck, J. Kunisawa, N. Shastri, and J.M. Frechet, A macromolecular delivery vehicle for protein-based vaccines: acid-degradable protein-loaded microgels. Proc Natl Acad Sci USA 100:4995-5000, 2003
  • G. Sakaue, T. Hiroi, Y. Nakagawa, K. Someya, K. Iwatani, Y. Sawa, H. Takahashi, M. Honda, J. Kunisawa, and H. Kiyono, HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses. J Immunol 170:495-502, 2003

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2002

  • J. Kunisawa, I. Takahashi, A. Okudaira, T. Hiroi, K. Katayama, T. Ariyama, Y. Tsutsumi, S. Nakagawa, H. Kiyono, and T. Mayumi, Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Eur J Immunol 32:2347-2355, 2002
  • Y. Enose, M. Ui, A. Miyake, H. Suzuki, H. Uesaka, T. Kuwata, J. Kunisawa, H. Kiyono, H. Takahashi, T. Miura, and M. Hayami, Protection by intranasal immunization of a nef-deleted, nonpathogenic SHIV against intravaginal challenge with a heterologous pathogenic SHIV. Virology 298:306-316, 2002
  • 國澤 純、高橋一郎、清野 宏、真弓忠範　抗原の性状と抗体産生におけるPeyer板の役割　臨床免疫　37(4): 387-391, 2002

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2001

  • J. Kunisawa, T. Nakanishi, I. Takahashi, A. Okudaira, Y. Tsutsumi, K. Katayama, S. Nakagawa, H. Kiyono, and T. Mayumi, Sendai virus fusion protein mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system. J Immunol 167:1406-1412, 2001
  • J. Kunisawa, S. Nakagawa, and T. Mayumi, Pharmacotherapy by intracellular delivery of drugs using fusogenic liposomes: application to vaccine development. Adv Drug Deliv Rev 52:177-186, 2001
  • J. Kunisawa, S. Fukuyama, G. Sakaue, T. Hiroi, and H. Kiyono, The NALT immunity for the development of mucosal vaccine. Recent Advanced in Otitis Media, Takasaka, T., Yuasa, R., and Hozawa, K. [eds.], Monduzzi Editore S.P.A., Bologna, Italy, pp. 31-35, 2001
  • 國澤 純、高橋一郎、真弓忠範、清野 宏　粘膜ワクチンの新しい展開　医学のあゆみ　199: 125-130, 2001
  • 林　哲、國澤　純、堤　康央、中川晋作、真弓忠範　DDSの免疫療法：ワクチン開発とDDS　分子がん治療　2 (3): 41-48, 2001
  • 國澤　純、真弓忠範　膜融合リポソームの癌治療への応用　癌と化学療法 28(5), 577-583, 2001
  • 國澤　純、今津　進、林　哲、清野　宏、真弓忠範　ワクチンにおけるFusogenic liposomeの応用　臨床免疫　35 (1): 122-126, 2001

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2000

  • T. Nakanishi, A. Hayashi, J. Kunisawa, Y. Tsutsumi, K. Tanaka, Y. Yashiro-Ohtani, M. Nakanishi, H. Fujiwara, T. Hamaoka, and T. Mayumi, Fusogenic liposomes efficiently deliver exogenous antigen through the cytoplasm into the MHC class I processing pathway. Eur J Immunol 30:1740-1747, 2000
  • J. Kunisawa, A. Okudaira, Y. Tsutsumi, I. Takahashi, T. Nakanishi, H. Kiyono, and T. Mayumi, Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses. Vaccine 19:589-594, 2000
  • 國澤　純、阪上　学、清野　宏　NALT immune system for the development of AIDS mucosal vaccine. 日本臨床免疫学会誌 23(6): 579-581, 2000

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1999

  • T. Nakanishi, J. Kunisawa, A. Hayashi, Y. Tsutsumi, K. Kubo, S. Nakagawa, M. Nakanishi, K. Tanaka, and T. Mayumi, Positively charged liposome functions as an efficient immunoadjuvant in inducing cell-mediated immune response to soluble proteins. J Control Release 61:233-240, 1999
  • A. Hayashi, T. Nakanishi, J. Kunisawa, M. Kondoh, S. Imazu, Y. Tsutsumi, K. Tanaka, H. Fujiwara, T. Hamaoka, and T. Mayumi, A novel vaccine delivery system using immunopotentiating fusogenic liposomes. Biochem Biophys Res Commun 261:824-828, 1999

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1998

  • 中西　剛、國澤　純、林　哲、堤　康央、早川尭夫、真弓忠範　Cationization of liposome surface charge enhances adjuvant effect of liposomes for tumor vaccine, 薬剤学 58(2): 59 – 68, 1998
  • 中西　剛、國澤　純、林　哲、堤　康央、早川尭夫、真弓忠範　Enhancement of liposomal adjuvant actions for tumor vaccines by increasing the degree of surface charge, Drug Delivery System 13(3): 151-157, 1998
  • 中西　剛、國澤　純、林　哲、堤　康央、早川尭夫、真弓忠範　Fusogenic liposome directs an exogenous antigen into class I majour histcompatibility complex antigen-presenting pathway, Drug Delivery System 13(1): 27-33, 1998
  • 國澤　純、中西　剛、林　哲、堤　康央、早川尭夫、真弓忠範　Fusogenic liposome functions as an efficient immunoadjuvant in inducing humoral immune responses to soluble antigen, Drug Delivery System. 13(1): 21-26, 1998

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1997

  • T. Nakanishi, J. Kunisawa, A. Hayashi, Y. Tsutsumi, K. Kubo, S. Nakagawa, H. Fujiwara, T. Hamaoka, and T. Mayumi, Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins. Biochem Biophys Res Commun 240:793-797, 1997
  • 高橋一郎、國澤　純、真弓忠範、清野　宏　粘膜ワクチンの理論と開発　医学のあゆみ183: 870 – 873, 1997

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