国立研究開発法人 医薬基盤・健康・栄養研究所
免疫老化プロジェクト
免疫老化プロジェクト
Principles governing establishment versus collapse of HIV-1 cellular spread.
Hataye JM, Casazza JP, Best K, Liang JC, Immonen TT, Ambrozak DR, Darko S, Henry AR, Laboune F, Maldarelli F, Douek DC, Hengartner NW, Yamamoto T, Keele BF, Perelson AS, Koup RA.
Cell Host Microbe. 2019 Dec 11;26(6):748-763.e20. doi: 10.1016/j.chom.2019.10.006. PubMed PMID: 31761718.
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies.
Adachi Y, Tonouchi K, Nithichanon A, Kuraoka M, Watanabe A, Shinnakasu R, Asanuma H, Ainai A, Ohmi Y, Yamamoto T, Ishii KJ, Hasegawa H, Takeyama H, Lertmemongkolchai G, Kurosaki T, Ato M, Kelsoe G, Takahashi Y.
Nat Commun. 2019 Aug 28;10(1):3883. doi: 10.1038/s41467-019-11821-6. PubMed PMID: 31462639.
A unique nanoparticulate TLR9 agonist enables a HA-split vaccine to confer FcRγ-mediated protection against heterologous lethal influenza virus infection.
Yamamoto T, Masuta Y, Momota M, Kanekiyo M, Kanuma T, Takahama S, Moriishi E, Yasutomi Y, Saito T, Graham BS, Takahashi Y, Ishii KJ.
Int Immunol. 2019 Feb 15;31(2):81-90. doi: 10.1093/intimm/dxy069. (Selected Editor’s choice) PubMed PMID: 30535055.
STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques.
Yamamoto T*, Kanuma T, Takahama S, Okamura T, Moriishi E, Ishii KJ, Terahara K, Yasutomi Y. (*corresponding author)
Sci Rep. 2019 Apr 11;9(1):5917. doi: 10.1038/s41598-019-42253-3. PubMed PMID: 30976083.
The STING ligand cGAMP potentiates the efficacy of vaccine-induced CD8+ T-cells.
Gutjahr A, Papagno L, Nicoli F, Kanuma T, Kuse N, Cabral-Piccin M, Rochereau N, Gostick E, Lioux T, Perouzel E, Price DA, Takiguchi M, Verrier B, Yamamoto T*, Paul S*, Appay V*. (*co-corresponding authors)
JCI Insight. 2019 Apr 4;4(7). pii: 125107. doi: 10.1172/jci.insight.125107. PubMed PMID: 30944257.
Elderly human hematopoietic progenitor cells express cellular senescence markers and are more susceptible to pyroptosis.
Fali T, Fabre-Mersseman V, Yamamoto T, Bayard C, Papagno L, Fastenackels S, Zoorab R, Koup RA, Boddaert J, Sauce D, Appay V. /p>
JCI Insight. 2018 Jul 12;3(13). pii: 95319. doi: 10.1172/jci.insight.95319. PubMed PMID: 29997288.
An antigen-free, pDC-targeting immunotherapy to bolster memory CD8+ T cells in non-human primates.
Masuta Y*, Yamamoto T*, Natsume-Kitatani Y, Kanuma T, Moriishi E, Kobiyama K, Mizuguchi K, Yasutomi Y, Ishii KJ. (*contributed equally to this work)
J Immunol. 2018 Mar 15;200(6):2067-2075. doi: 10.4049/jimmunol.1701183. PubMed PMID: 29431693.
Fine-tuning of CD8(+) T-cell effector functions by targeting the 2B4-CD48 interaction.
Lissina A*, Ambrozak DR, Boswell KL, Yang W, Boritz E, Wakabayashi Y, Iglesias MC, Hashimoto M, Takiguchi M, Haddad E, Douek DC, Zhu J, Koup RA, Yamamoto T*, Appay V. (*co-corresponding authors)
Immunol Cell Biol. 2016 Jul;94(6):583-92. PubMed PMID: 26860368.
Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site.
Kanekiyo M, Bu W, Joyce MG, Meng G, Whittle JR, Baxa U, Yamamoto T, Narpala S, Todd JP, Rao SS, McDermott AB, Koup RA, Rossmann MG, Mascola JR, Graham BS, Cohen JI, Nabel GJ.
Cell. 2015 Aug 12. pii: S0092-8674(15)00959-9. PubMed PMID: 26279189.
Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection
Yamamoto T, Lynch RM, Gautam R, Matus-Nicodemos R, Schmidt SD, Boswell KL, Darko S, Wong P, Sheng Z, Petrovas C, McDermott AB, Seder RA, Keele BF, Shapiro L, Douek DC, Nishimura Y, Mascola JR, Martin MA, Koup RA.
Sci Transl Med. 2015 Jul 29;7(298):298ra120. (Selected Top 20 NIAID scientific highlights of fiscal year 2015) PubMed PMID: 26223303.
Analysis of immunoglobulin transcripts and hypermutation following SHIVAD8 infection and protein-plus-adjuvant immunization
Francica JR, Sheng Z, Zhang Z, Nishimura Y, Shingai M, Ramesh A, Keele BF, Schmidt SD, Flynn BJ, DarkoS, Lynch RM, Yamamoto T, Matus-Nicodemos R, Wolinsky D, NISC Comparative Sequencing Program, Nason M, Valiante NM, Malyala P, Gregorio ED, Barnett SW, Singh M, O’Hagan DT, Koup RA, Mascola1 JR, Martin MA, Kepler TB, Douek DC, Shapiro L, and Seder RA.
Nat Commun. 2015 Apr 10;6:6565 PubMed PMID: 25858157.
HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.
Cooper A, García M, Petrovas C, Yamamoto T, Koup RA, Nabel GJ.
Nature. 2013 Jun 20;498(7454):376-9. PubMed PMID: 23739328.
CD4 T follicular helper cell dynamics during SIV infection.
Petrovas C, Yamamoto T, Gerner MY, Boswell KL, Wloka K, Smith EC, Ambrozak DR, Sandler NG, Timmer KJ, Sun X, Pan L, Poholek A, Rao SS, Brenchley JM, Alam SM, Tomaras GD, Roederer M, Douek DC, Seder RA, Germain RN, Haddad EK, Koup RA.
J Clin Invest. 2012 Sep 4; 122(9):3281-94. PubMed PMID: 22922258.
Virus inhibition activity of effector memory CD8+ T cells determines Simian Immunodeficiency Virus load in vaccinated monkeys after vaccine breakthrough infection.
Yamamoto T, Johnson MJ, Price DA, Wolinsky DI, Almeida JR, Petrovas C, Nason M, Yeh WW, Shen L, Roederer M, Rao SS, McDermott AB, Lefebvre F, Nabel GJ, Haddad EK, Letvin NL, Douek DC, Koup RA.
J Virol. 2012 May;86(10):5877-84. PubMed PMID: 22419810.
Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T cell exhaustion in HIV infection.
Yamamoto T, Price DA, Casazza JP, Ferrari G, Nason M, Chattopadhyay PK, Roederer M, Gostick E, Katsikis PD, Douek DC, Haubrich R, Petrovas C, and Koup RA.
Blood. 2011 May 5;117(18):4805-15. Epub 2011 Mar 11. PubMed PMID: 21398582.
Selective transmission of R5 HIV-1 over X4 HIV-1 at the dendritic cell-T cell infectious synapse is determined by the T cell activation state.
Yamamoto T*, Tsunetsugu-Yokota Y*, Mitsuki YY, Mizukoshi F, Tsuchiya T, Terahara K, Inagaki Y, Yamamoto N, Kobayashi K, Inoue J. (*; equally contributed this work)
PLoS Pathog. 2009 Jan;5(1):e1000279. Epub 2009 Jan 30. PubMed PMID: 19180188.
Polyfunctional CD4+ T-cell induction in neutralizing antibody-triggered control of simian immunodeficiency virus infection.
Yamamoto T, Iwamoto N, Yamamoto H, Tsukamoto T, Kuwano T, Takeda A, Kawada M, Tsunetsugu-Yokota Y, Matano T.
J Virol. 2009 Jun;83(11):5514-24. Epub 2009 Mar 18. PubMed PMID: 19297503.
Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages.
Yamamoto T, Miyoshi H, Yamamoto N, Yamamoto N, Inoue J, Tsunetsugu-Yokota Y.
Blood. 2006 Nov 15;108(10):3305-12. PubMed PMID: 16857988.
Pattern Recognition Receptor Ligands as an Emerging Therapeutic Agent for Latent HIV-1 Infection.
Shokichi Takahama and Yamamoto T*. (*corresponding author)
Front Cell Infect Microbiol. 2020 May 8;10:216. PubMed PMID: 32457851.
Phenotypic and Functional Analysis of Antigen-Specific T Cell Exhaustion.
Boswell KL, Yamamoto T*. (*corresponding author)
Methods Mol Biol. 2017;1514:83-92. (Book Chapter) PubMed PMID: 27787793.
HIV vaccine research and discovery in the nonhuman primates model: a unified theory in acquisition prevention and control of SIV infection.
Lynch RM, Yamamoto T, McDermott AB.
Curr Opin HIV AIDS. 2013 Jul;8(4):288-94. PubMed PMID: 23666390.