Center for Drug Discovery Resources Research

Our center performs research and develop on cell lines, model cells such as organ/tissue cells and functional organoids from iPS cells and adult stem cellｓ, and model animals that mimic human diseases, which are indispensable for the discovery of drugs. We contribute to the promotion of drug discovery research by providing these biological resources to researchers in Japan and overseas through the JCRB cell bank, human tissue bank, and experimental animal research resource bank.

Laboratory of Drug Discovery Resources Research(JCRB Cell Bank)

https://www.nibiohn.go.jp/en/activities/culture-resources.html

The Laboratory operates the JCRB cell bank, which has the largest number of cell samples in Japan, and a human tissue bank which provides tissue leftover from surgery to researchers in Japan. The laboratory facilitates drug discovery research in Japan and abroad by providing quality biological resources. We are also working to develop tools required for drug discovery research.

Laboratory of Cell Model for Drug Discovery

https://www.nibiohn.go.jp/en/activities/stem-cell-control.html

Activities seek to develop efficient methods that differentiate stem cells into functional cells using the knowledge of embryology and molecular biology, and to create novel drug discovery platform technologies (e.g., screening systems) using engineered functional cells.

Laboratory of Functional Organoid for Drug Discovery

https://www.nibiohn.go.jp/en/activities/hepatocyte-regulation.html

To accelerate drug discovery, new in vitro systems are developed using cells (e.g., hepatocytes and intestinal epithelial cells) that are differentiated from human induced pluripotent stem cells. These systems are used to predict drug efficacy and toxicity.

Laboratory of Animal Resource Bank

The Laboratory develops small animal models of diseases essential for the study of diseases, including intractable diseases. We also operate an animal research resource bank for testing and the development of treatments. The laboratory facilitates disease research and drug discovery by developing and analyzing models, collecting, storing, and supplying animals with spontaneous diseases and genetic modifications, and developing related technologies.

Laboratory of Dug Discovery Resources Research Collaboration Promotion Office

To accelerate drug discovery research, we are developing efficiently resources of evaluation systems models by using cells with some function or with a disease phenotype through internal and external collaborations.