Identification of D-serine as a dual biomarker for the estimation of kidney function and for the early diagnosis of kidney diseases
Mar. 26, 2019
Currently, early diagnosis of chronic kidney disease (CKD) is ineffective because there is no precise and reliable method to estimate kidney function. Tomonori Kimura, director of Center for Rare Disease Research and project leader of KAGAMI Project in National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), found that D-serine, one of D-amino acids※1, which present only trace in human, is a useful biomarker for both the estimation of kidney function and the early diagnosis of kidney diseases. The present discovery would facilitate more accurate estimation of kidney function and earlier diagnosis of CKD treatment. Once applied in the clinics, this discovery would improve the prognosis of CKD and reduce the number of patients with end-stage kidney disease requiring kidney replacement therapy. Furthermore, D-serine may also be applicable for the discovery of novel therapy. The potential application is not limited to the kidney diseases: the disease context ranges to life style-related diseases such as diabetes mellitus and hypertension, as well as lethal diseases including cardiovascular diseases.
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